在少量水存在下，通过光诱导激活硅基烯醇醚实现酮与烯烃的α-烷基化反应。
α-Alkylation of Ketones with Alkenes Enabled by Photoinduced Activation of Silyl Enol Ethers in the Presence of a Small Amount of Water.
作者信息
Hirata Tsubasa, Ogasawara Yoshihiro, Yamashita Yasuhiro, Kobayashi Shu
机构信息
Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Org Lett. 2021 Aug 6;23(15):5693-5697. doi: 10.1021/acs.orglett.1c01824. Epub 2021 Jul 15.
PMID:34264686
Abstract
Under blue-light irradiation conditions with a photocatalyst [1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene], silyl enol ethers reacted with alkenes in the presence of a small amount of water to afford the α-alkylation products in good to high yields. A thiol cocatalyst was found to expand the substrate scope of the reaction.
摘要
在光催化剂[1,2,3,5-四（咔唑-9-基）-4,6-二氰基苯]的蓝光照射条件下，硅烯醇醚在少量水存在下与烯烃反应，以良好至高收率得到α-烷基化产物。发现硫醇助催化剂可扩大反应的底物范围。
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