Laboratory of Toxicology, Faculty of Medicine, Salah Boubnider University 3, Constantine, Algeria; Laboratory of Preventive Medicine for Chronic Diseases, Salah Boubnider University 3, Constantine, Algeria.
LAQV-REQUIMTE, Laboratory of Bromatology and Hidrology, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Environ Res. 2021 Nov;202:111666. doi: 10.1016/j.envres.2021.111666. Epub 2021 Jul 12.
Bisphenol A (BPA) is a known endocrine disruptor compound that is widely applied as a monomer base in polycarbonate plastics and as a binding agent in several epoxy resins. Plastic industry workers have usually heavier and prolonged exposures to BPA. Hence, the present work aims to assess the levels of BPA and their analogs (S, F, B, AF, Z, E, and AP) in 170 urine samples from a cross-sectional study of workers from a plastic industry located in north Constantine (Algeria). This work was complemented with a questionnaire about sexual functions and evaluation of sexual hormone levels. The results showed a stable presence of BPA (average of 3.24 μg/L), accounting for more than 90% of the total BPs. Of the remaining BP analogs, only trace amounts of BPB were detected in three samples (average of 2.73 μg/L). Significant associations with BPA urinary levels were noted with age (p = 0.006), occupational level of exposure (p = 0.023), and years of experience (p = 0.001).
双酚 A (BPA) 是一种已知的内分泌干扰化合物，广泛用作聚碳酸酯塑料的单体基础和几种环氧树脂的结合剂。塑料行业工人通常会接触到更重、更长时间的 BPA。因此，本研究旨在评估来自阿尔及利亚 Constantine 北部一家塑料行业的 170 名工人的横断面研究中 170 份尿液样本中的 BPA 及其类似物（S、F、B、AF、Z、E 和 AP）的水平。这项工作还补充了一份关于性功能的问卷和性激素水平的评估。结果显示 BPA （平均 3.24μg/L）的存在稳定，占总 BP 的 90%以上。在另外三个样本中，仅检测到痕量的 BPB（平均 2.73μg/L）。BPA 尿水平与年龄（p=0.006）、职业接触水平（p=0.023）和工作年限（p=0.001）显著相关。
