车前子种子治疗溃疡性结肠炎症状的疗效：一项随机、安慰剂对照、临床试验。
Efficacy of Plantago major seed in management of ulcerative colitis symptoms: A randomized, placebo controlled, clinical trial.
机构信息
Department of Traditional Persian Medicine, School of Medicine, Shahed University, Tehran, Iran.
Department of Social Medicine, School of Medicine, Shahed University, Tehran, Iran.
出版信息
Complement Ther Clin Pract. 2021 Aug;44:101444. doi: 10.1016/j.ctcp.2021.101444. Epub 2021 Jul 10.
OBJECTIVE
Evaluation of the effect of Plantago major (P. major) seed on ulcerative colitis (UC) symptoms.
METHODS
In this randomized double-blind clinical trial, 61 subjects received 3600 mg/day roasted P. major seed in intervention group (n = 31) and roasted wheat flour in control group (n = 30), for 8 weeks, as a complementary to standard medications. Variables were assessed using the Lichtiger Colitis Activity Index (LCAI) at baseline, week 4, and week 8.
RESULTS
51 patients completed the trial (n = 28 in Plantago and n = 23 in placebo groups). Abdominal tenderness (p = 0.011), gastroesophageal reflux and gastric pain (p = 0.049 for both), were significantly less severe in P. major group. Visible blood in stool (p = 0.001), distension (p = 0.001), and anal pain (p = 0.051), decreased significantly in P. major group, although no significant difference was observed between the two groups: (p = 0.224), (p = 0.283), and (p = 0.455) respectively.
CONCLUSION
P. major seems to be effective in complementary management of UC.
目的
评估车前草（P. major）种子对溃疡性结肠炎（UC）症状的影响。
方法
在这项随机双盲临床试验中，61 名受试者分别接受 3600mg/天烘焙车前草种子（干预组，n=31）和烘焙小麦粉（对照组，n=30）治疗，作为标准药物治疗的补充，治疗时间为 8 周。在基线、第 4 周和第 8 周使用 Lichtiger 结肠炎活动指数（LCAI）评估变量。
结果
51 名患者完成了试验（车前草组 n=28，安慰剂组 n=23）。车前草组的腹部压痛（p=0.011）、胃食管反流和胃痛（两者均为 p=0.049）明显减轻。车前草组粪便中肉眼可见血（p=0.001）、腹胀（p=0.001）和肛门疼痛（p=0.051）显著减少，但两组间无显著差异：（p=0.224）、（p=0.283）和（p=0.455）。
结论
车前草在溃疡性结肠炎的辅助治疗中似乎有效。
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