Louis-Jean Scarlet
Department of Internal Medicine, Anne Arundel Medical Center, Annapolis, MD, USA.
Ann Gastroenterol. 2024 Jul-Aug;37(4):392-402. doi: 10.20524/aog.2024.0893. Epub 2024 Jun 14.
Inflammatory bowel disease is a debilitating condition that undergoes a relapsing and remitting course. The pathogenesis of how this disease manifests remains to be elucidated; however, there is growing evidence that a synergism of familial predisposition and epigenetic alterations influenced by environmental factors all contribute to the development of the disease. The role of nutrition in improving the outcomes of the condition has garnered increasing interest, given the greater risks of neoplastic conversion and concerns about inappropriate remission with available pharmacotherapeutic treatments alone. Available reports, often anecdotal, have documented patient relief with employment of various dietary strategies. These have led to curiosity about nutritional assessments and nutrition therapies to ameliorate the morbidity and all-cause mortality of the disease. One group of such nutrition therapies, supported by a compendium of available articles, is flavonoids-although the greater abundance of experiments with relatively few clinical trials has limited their clinical use. Nonetheless, flavonoids have been shown to be functional foods with immunomodulatory capabilities. This article will thus delve into the role of flavonoids in altering the course of the immune response in inflammatory bowel disease, while assessing their clinical outcomes in human trials.
炎症性肠病是一种使人衰弱的疾病，呈复发和缓解病程。该疾病如何表现的发病机制仍有待阐明；然而，越来越多的证据表明，家族易感性与受环境因素影响的表观遗传改变之间的协同作用都促成了该疾病的发展。鉴于肿瘤转化风险更高以及仅使用现有药物治疗存在不适当缓解的问题，营养在改善该疾病结局方面的作用已引起越来越多的关注。现有报告（通常为轶事性的）记录了采用各种饮食策略后患者症状得到缓解的情况。这些情况引发了人们对营养评估和营养疗法的好奇，以改善该疾病的发病率和全因死亡率。有一组这样的营养疗法，得到了一系列现有文章的支持，即类黄酮——尽管大量的实验相对较少的临床试验限制了它们的临床应用。尽管如此，类黄酮已被证明是具有免疫调节能力的功能性食品。因此，本文将深入探讨类黄酮在改变炎症性肠病免疫反应进程中的作用，同时评估它们在人体试验中的临床效果。
