重组肿瘤坏死因子（恶病质素）对分离的大鼠脂肪细胞、肝细胞和肌肉制剂代谢的影响。
The effects of recombinant tumour necrosis factor (cachectin) on metabolism in isolated rat adipocyte, hepatocyte and muscle preparations.
作者信息
Rofe A M, Conyers R A, Bais R, Gamble J R, Vadas M A
机构信息
Division of Clinical Chemistry, Institute of Medical and Veterinary Science, Adelaide, S.A.
出版信息
Biochem J. 1987 Nov 1;247(3):789-92. doi: 10.1042/bj2470789.
Abstract
Tumour necrosis factor (TNF) did not stimulate lipolysis in isolated rat adipocytes, though preincubation with TNF increased adrenaline-stimulated fatty acid release. Glycogenolysis, gluconeogenesis and ketogenesis in isolated rat hepatocytes were not influenced by TNF in short-term (30-60 min) incubations. TNF stimulated 14CO2 production from [U-14C]glucose in rat hemidiaphragm preparations, but lactate production and alanine release were not significantly altered. It is concluded that TNF does not regulate short-term metabolism in adipocytes, hepatocytes and muscle preparations in the manner of a catabolic hormone.
摘要
肿瘤坏死因子（TNF）不会刺激分离的大鼠脂肪细胞中的脂肪分解，尽管与TNF预孵育会增加肾上腺素刺激的脂肪酸释放。在短期（30 - 60分钟）孵育中，TNF对分离的大鼠肝细胞中的糖原分解、糖异生和生酮作用没有影响。TNF刺激大鼠半膈肌标本中[U - 14C]葡萄糖生成14CO2，但乳酸生成和丙氨酸释放没有显著改变。得出的结论是，TNF不会以分解代谢激素的方式调节脂肪细胞、肝细胞和肌肉标本中的短期代谢。
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