Rofe A M, Porter S J, Bais R, Conyers R A
Br J Cancer. 1985 Oct;52(4):619-23. doi: 10.1038/bjc.1985.235.
The suggestion that the ketonaemic response to fasting may be altered in the tumour-bearing state was investigated by studying the metabolism of fasted C57/BL6j mice bearing transplanted B16 melanomas. Ketone body (D-3-hydroxybutyrate and acetoacetate) concentrations in the blood of the tumour-bearing mice were significantly increased after a 24 h fast compared to control mice with identical dietary histories. Hepatic glycogen levels were lower at the start of the fasting period in the tumour-bearing mice as were the fat stores. The loss of adipose tissue during the fasting period was greater in the tumour-bearing mice. After 48 h of fasting, the ketonaemia was significantly lower in the tumour-bearing mice compared to the appropriate controls. Two distinct metabolic states are indicated in these fasted tumour-bearing mice, one characterised by accelerated ketonaemia, and a later, near terminal stage, where fat deposits are markedly depleted and ketonaemia is decreased.
通过研究移植了B16黑色素瘤的禁食C57/BL6j小鼠的代谢情况，对荷瘤状态下禁食的酮血症反应是否会改变这一问题进行了调查。与具有相同饮食史的对照小鼠相比，荷瘤小鼠禁食24小时后血液中的酮体（D-3-羟基丁酸和乙酰乙酸）浓度显著升高。在禁食期开始时，荷瘤小鼠的肝糖原水平和脂肪储备均较低。荷瘤小鼠在禁食期间脂肪组织的损失更大。禁食48小时后，与相应对照组相比，荷瘤小鼠的酮血症显著降低。这些禁食的荷瘤小鼠表现出两种不同的代谢状态，一种以加速的酮血症为特征，另一种是较晚的接近终末期，此时脂肪沉积明显减少，酮血症降低。
