Universidade Federal da Paraíba, Departamento de Química, 58051-970 João Pessoa, Paraíba, Brazil.
Instituto Federal da Paraíba, Química, 58999-000 Sousa, Paraíba, Brazil.
Food Chem. 2021 Dec 15;365:130472. doi: 10.1016/j.foodchem.2021.130472. Epub 2021 Jul 5.
Parabens are compounds used as chemical preservatives in cosmetics, drugs, and food. Some can cause adverse effects on human health. In this study, a square wave voltammetric method using a glassy carbon electrode was developed for simultaneous determination of methyl, ethyl, propyl, and butyl parabens in sweeteners. To overcome the strong overlap of voltammetric signals caused by calibrated and uncalibrated constituents, unfolded partial least squares with residual bilinearization (U-PLS/RBL) was used. The U-PLS/RBL calibration model was constructed and evaluated using a validation set obtained using a Taguchi design. Satisfactory and unbiased results were obtained with a linear response in the range of 0.78-4.48 μmol L and recoveries from 82.64% to 121.77%. As far as the authors know, a voltammetric method that simultaneously determines four parabens in complex samples such as sweeteners without any previous pretreatment has not yet been reported in the literature.
对羟基苯甲酸酯是化妆品、药物和食品中用作化学防腐剂的化合物。一些对羟基苯甲酸酯会对人类健康产生不良影响。在这项研究中，开发了一种使用玻碳电极的方波伏安法，用于同时测定甜味剂中的甲基、乙基、丙基和丁基对羟基苯甲酸酯。为了克服由校准和未校准成分引起的伏安信号强烈重叠，使用了无约束部分最小二乘与残差双线性化（U-PLS/RBL）。使用 Taguchi 设计获得的验证集构建和评估了 U-PLS/RBL 校准模型。在 0.78-4.48 μmol L 的线性范围内获得了令人满意且无偏的结果，回收率为 82.64%至 121.77%。据作者所知，尚未有文献报道在无需任何预处理的情况下，使用伏安法同时测定甜味剂等复杂样品中的四种对羟基苯甲酸酯。
