Robinson W E, Montefiori D C, Mitchell W M
Vanderbilt University School of Medicine, Department of Pathology, Nashville, TN 37232.
Biochem Biophys Res Commun. 1987 Dec 16;149(2):693-9. doi: 10.1016/0006-291x(87)90423-2.
While testing sera for Human Immunodeficiency Virus neutralizing antibody titers, three sera were identified which had the ability to enhance infectivity of the virus. The sera were from three different individuals residing in Nashville, TN. The enhancing factor was not removed by either filtration through 0.05 micron filters or by incubation for one hour with a stoichiometric amount of protein A sepharose. Two of the sera were able to enhance infection by two divergent isolates (HTLV-IIIB and HTLV-IIIRF) while one was only capable of enhancing infection of target cells by HTLV-IIIB. None of the sera induced syncytium formation in chronic HIV-infected cells. The findings suggest that the substance is neither a virus nor an IgG class 1 or 2.
在检测人免疫缺陷病毒中和抗体滴度的血清时，发现三份血清具有增强病毒感染性的能力。这些血清来自田纳西州纳什维尔市的三名不同个体。增强因子既不能通过0.05微米滤器过滤去除，也不能与化学计量的蛋白A琼脂糖孵育一小时来去除。其中两份血清能够增强两种不同分离株（HTLV-IIIB和HTLV-IIIRF）的感染，而另一份血清仅能增强HTLV-IIIB对靶细胞的感染。这些血清均未在慢性HIV感染细胞中诱导合胞体形成。研究结果表明，该物质既不是病毒，也不是IgG 1类或2类。
