氢化可的松对衰老大鼠肝脏中天冬氨酸转氨酶同工酶的调节作用。
Regulation of aspartate aminotransferase isoenzymes by hydrocortisone in the liver of aging rats.
作者信息
Sharma R, Patnaik S K
出版信息
Arch Gerontol Geriatr. 1987 Apr;6(1):27-32. doi: 10.1016/0167-4943(87)90036-7.
The activities and induction patterns of the isoenzymes of aspartate aminotransferase of the liver of male rats of various ages were studied. The activity of cytoplasmic aspartate aminotransferase increases gradually till adulthood and remains constant thereafter with increasing age of the rat. However, the activity of mitochondrial isoenzyme remains constant throughout the life span of the rat. Adrenalectomy decreases and hydrocortisone increases the activity of cytoplasmic isoenzyme in rats of all ages. In contrast, the above treatments do not shown any affect on the activity of mitochondrial isoenzyme in the liver of rats of all ages.
研究了不同年龄雄性大鼠肝脏中天冬氨酸氨基转移酶同工酶的活性及诱导模式。细胞质天冬氨酸氨基转移酶的活性在成年前逐渐增加，此后随着大鼠年龄增长保持恒定。然而，线粒体同工酶的活性在大鼠整个寿命期内保持恒定。肾上腺切除术降低了各年龄段大鼠细胞质同工酶的活性，而氢化可的松则增加了其活性。相反，上述处理对各年龄段大鼠肝脏中线粒体同工酶的活性均无影响。
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