Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Stomatological Hospital, Southern Medical University, Guangzhou, China.
J Nanobiotechnology. 2021 Jul 15;19(1):211. doi: 10.1186/s12951-021-00902-8.
Breast cancer is the most common malignancy in women, and its incidence increases annually. Traditional therapies have several side effects, leading to the urgent need to explore new smart drug-delivery systems and find new therapeutic strategies. Graphene-based nanomaterials (GBNs) are potential drug carriers due to their target selectivity, easy functionalization, chemosensitization and high drug-loading capacity. Previous studies have revealed that GBNs play an important role in fighting breast cancer. Here, we have summarized the superior properties of GBNs and modifications to shape GBNs for improved function. Then, we focus on the applications of GBNs in breast cancer treatment, including drug delivery, gene therapy, phototherapy, and magnetothermal therapy (MTT), and as a platform to combine multiple therapies. Their advantages in enhancing therapeutic effects, reducing the toxicity of chemotherapeutic drugs, overcoming multidrug resistance (MDR) and inhibiting tumor metastasis are highlighted. This review aims to help evaluate GBNs as therapeutic strategies and provide additional novel ideas for their application in breast cancer therapy.
乳腺癌是女性最常见的恶性肿瘤，其发病率逐年上升。传统疗法有多种副作用，因此迫切需要探索新的智能药物输送系统并寻找新的治疗策略。基于石墨烯的纳米材料（GBNs）由于其靶向选择性、易于功能化、化疗增敏和高载药能力，成为潜在的药物载体。先前的研究表明，GBNs 在抗击乳腺癌方面发挥着重要作用。在这里，我们总结了 GBNs 的优越性质及其修饰以改善功能的方式。然后，我们重点介绍了 GBNs 在乳腺癌治疗中的应用，包括药物输送、基因治疗、光疗和磁热疗（MTT），以及作为多种疗法结合的平台。强调了它们在增强治疗效果、降低化疗药物毒性、克服多药耐药性（MDR）和抑制肿瘤转移方面的优势。本综述旨在帮助评估 GBNs 作为治疗策略，并为其在乳腺癌治疗中的应用提供新的思路。
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