Basilio C M, Toro A, Bernstein J, Yojay L
Department of Biochemistry, School of Medicine, University of Puerto Rico, San Juan.
Alcohol Alcohol. 1987;22(4):395-400.
The effect of nicotinic acid (NA) on sleeping time induced by a single dose of ethanol or pentobarbital was studied in rats. It was found that sleeping time was markedly reduced by NA in a dose-dependent manner. The effect was observed when NA was administered 10 min before or after ethanol or pentobarbital, but not when given 60 min in advance. NA did not affect the rate of ethanol elimination measured up to 5 hr after ethanol administration. Rats pretreated with NA 60 min before ethanol slept longer than controls. This latter effect was not observed with pentobarbital. These observations, together with the known lack of effect of high liver NAD+ levels on ethanol metabolism and the rather stable NAD+ concentration in brain cells, suggest that the effect of NA on sleeping time is not mediated by an increase in ethanol metabolism in liver or by NAD+ or NAD+-dependent reactions in brain. Our results are consistent with a direct action of NA, or some rapidly formed derivative, on a structure or process associated with brain cell functions or membranes.
研究了烟酸（NA）对大鼠单次给予乙醇或戊巴比妥诱导的睡眠时间的影响。发现NA以剂量依赖性方式显著缩短睡眠时间。当在乙醇或戊巴比妥给药前10分钟或给药后给予NA时可观察到该效应，但提前60分钟给药则无此效应。NA不影响乙醇给药后长达5小时内测得的乙醇消除率。在乙醇给药前60分钟用NA预处理的大鼠比对照组睡眠时间更长。戊巴比妥未观察到后一种效应。这些观察结果，连同已知的肝脏高NAD +水平对乙醇代谢无影响以及脑细胞中NAD +浓度相当稳定的情况，表明NA对睡眠时间的影响不是由肝脏中乙醇代谢增加或由脑细胞中的NAD +或NAD +依赖性反应介导的。我们的结果与NA或某些快速形成的衍生物对与脑细胞功能或膜相关的结构或过程的直接作用一致。
