Beaubien A R, Carpenter D C, Mathieu L F
Res Commun Chem Pathol Pharmacol. 1976 Mar;13(3):365-78.
The toxicity of pentobarbital was examined in male Wistar rats pretreated with a non-toxic dose of imipramine (10 mg/kg, po). Pentobarbital (70 mg/kg, ip) lethality was enhanced up to 6 hr after imipramine administration, and pentobarbital (45 mg/kg, ip) sleeping time was prolonged up to 12 hr after imipramine. Physiological measurements showed that imipramine pretreatment 2 hr prior to pentobarbital (70 mg/kg, ip) enhanced barbiturate depression in mean blood pressure, oxygen consumption and respiration rate, but not in heart rate or back skin temperature. Analysis of brain radioactivity after [14C] pentobarbital indicated that these effects of imipramine were not solely the result of inhibition of liver metabolism.
在给予无毒剂量的丙咪嗪（10毫克/千克，口服）预处理的雄性Wistar大鼠中检测了戊巴比妥的毒性。丙咪嗪给药后长达6小时，戊巴比妥（70毫克/千克，腹腔注射）的致死率增加，丙咪嗪给药后长达12小时，戊巴比妥（45毫克/千克，腹腔注射）的睡眠时间延长。生理测量表明，在戊巴比妥（70毫克/千克，腹腔注射）前2小时进行丙咪嗪预处理，可增强巴比妥类药物对平均血压、耗氧量和呼吸频率的抑制作用，但对心率或背部皮肤温度无影响。对[14C]戊巴比妥后大脑放射性的分析表明，丙咪嗪的这些作用并非仅仅是抑制肝脏代谢的结果。
