Aufrere G, Le Bourhis B
Centre de Recherche Pernod Ricard, Creteil, France.
Alcohol Alcohol. 1987;22(4):401-7.
Recent animal studies have shown that alcohol intoxication in utero leads to a decrease in foetal weight and an increase in that of placenta. These findings are not, however, satisfactorily explained. The object of this study was to investigate these two effects, using inhalation of various concentrations of ethanol vapour as a method of intoxication. Three groups of 12 gravid female rats (treated groups) were intoxicated by permanent exposure to an alcohol atmosphere (19, 20 or 21 mg/l.). Three control groups of 12 gravid females were not intoxicated but had their diet reduced to the same energy intake as the treated groups. On day 21 of pregnancy, foetuses and placentas were surgically removed and individually weighed. The body-weight of foetuses was found to be lower in the treated groups than in the respective controls. Additionally the reduction of foetal weight was directly related to the severity of intoxication. Increases in placental weight were observed in the three intoxicated groups. The differences observed between foetal and placental weights may be interpreted as a foeto-protective phenomenon.
近期的动物研究表明，子宫内酒精中毒会导致胎儿体重下降，胎盘重量增加。然而，这些发现并未得到令人满意的解释。本研究的目的是通过吸入不同浓度的乙醇蒸气作为中毒方法，来研究这两种影响。三组每组12只妊娠雌性大鼠（处理组）通过长期暴露于酒精环境（19、20或21毫克/升）而中毒。三组每组12只妊娠雌性大鼠作为对照组，未中毒，但饮食摄入量减少至与处理组相同的能量摄入水平。在妊娠第21天，通过手术取出胎儿和胎盘并分别称重。结果发现，处理组胎儿的体重低于各自对照组。此外，胎儿体重的减轻与中毒的严重程度直接相关。在三个中毒组中均观察到胎盘重量增加。观察到的胎儿和胎盘重量差异可解释为一种胎儿保护现象。
