Sanchis R, Sancho-Tello M, Guerri C
Alcohol Alcohol. 1986;21(3):295-305.
The effect of chronic ethanol intake during gestation was studied in rats fed a liquid diet in which ethanol provided 36% of the total calories. The animals were chronically alcoholised before mating, and the body weight gain and nutritional status during pregnancy were noted. Blood ethanol levels were measured during pregnancy and parturition. Specifically, we have shown that chronic ethanol intake during pregnancy lengthens the gestation period, decreases foetal viability, increases the placental weight and diminishes foetus, liver and brain weights, as well as the protein and DNA content of foetal brain. The reduced body weight of rats prenatally exposed to alcohol continued for the first two months of the postnatal period and was most apparent during lactation.
对妊娠期间长期摄入乙醇的影响进行了研究，以喂食液体饲料的大鼠为对象，该液体饲料中乙醇提供总热量的36%。这些动物在交配前长期摄入酒精，记录了孕期的体重增加和营养状况。在孕期和分娩期间测量了血液中的乙醇水平。具体而言，我们已经表明，孕期长期摄入乙醇会延长妊娠期，降低胎儿存活率，增加胎盘重量，并减少胎儿、肝脏和大脑的重量，以及胎儿大脑中的蛋白质和DNA含量。产前暴露于酒精的大鼠体重减轻在出生后的头两个月持续存在，并且在哺乳期最为明显。
