Budtz-Jörgensen E
J Oral Rehabil. 1978 Jan;5(1):35-9. doi: 10.1111/j.1365-2842.1978.tb00389.x.
It was the purpose of the study to test the efficacy of dissolvent tablets containing mutanase and protease in removing denture plaque. The study group consisted of forty institutionalized geriatric denture wearers, who were assigned randomly into an enzyme group and a placebo group. Enzyme tablets and placebo for denture soaking were administered by the nurses. The dentures were immersed for 15 min once daily for three months. The amount of denture plaque, the clinical condition of the palatal mucosa, and the concentration of yeasts and bacteria in mucosal and denture smears were recorded before, during, and after the experimental period. The study was designed and carried out as a double-blind study. After denture soaking for six weeks a significant reduction of the amount of denture plaque and improvement of the clinical condition of the palatal mucosa was recorded. After denture soaking for twelve weeks the conditions had improved further when comparing the enzyme group with the placebo group.
本研究旨在测试含有变聚糖酶和蛋白酶的溶解片在去除假牙菌斑方面的功效。研究组由40名住在养老院的老年假牙佩戴者组成，他们被随机分为酶组和安慰剂组。护士负责发放用于浸泡假牙的酶片和安慰剂。假牙每天浸泡15分钟，持续三个月。在实验期之前、期间和之后记录假牙菌斑的数量、腭黏膜的临床状况以及黏膜和假牙涂片上酵母和细菌的浓度。该研究设计并实施为双盲研究。假牙浸泡六周后，记录到假牙菌斑数量显著减少，腭黏膜的临床状况有所改善。与安慰剂组相比，假牙浸泡十二周后情况进一步改善。
