Rehnberg M, Ammitzböll T, Tengroth B
Department of Ophthalmology, Karolinska Institute and Hospital, Stockholm, Sweden.
Br J Ophthalmol. 1987 Dec;71(12):886-92. doi: 10.1136/bjo.71.12.886.
Tengroth and Ammitzböll found the collagen content of the optic disc in glaucoma to differ from that of normal eyes. A theory was advanced that a primary collagen disturbance might be involved in the pathogenesis of glaucoma. The connective tissue in the body has a supportive function in almost all the organs. The tensile strength and elasticity of connective tissue is mainly due to the presence of collagen fibres and elastic fibres, which also maintain the shape of the tissues. There are many different types of collagen, three of which are discussed in this paper. Type I collagen is found in tendons, skin, and numerous other organs, for example the eye. Type III is found mainly in the blood vessels but is also present in other tissues with a mesodermal origin, and type IV is found in the basement membranes. To elucidate the precise distribution of collagen types in the ocular structures an immunhistochemical study was undertaken in normal human eyes. The amino acids proline, hydroxyproline, and hydroxylysine, which are characteristic of collagen, were also analysed. Collagen types I, III, and IV were found in the lamina cribrosa, the trabecular meshwork, and the retrolaminary optic nerve. In contrast, only type I was found in the sclera.
滕格罗思和阿米茨博尔发现青光眼患者视盘的胶原蛋白含量与正常眼睛不同。有人提出一种理论，认为原发性胶原蛋白紊乱可能参与青光眼的发病机制。身体中的结缔组织在几乎所有器官中都具有支撑功能。结缔组织的抗张强度和弹性主要归因于胶原纤维和弹性纤维的存在，它们也维持着组织的形状。胶原蛋白有许多不同类型，本文讨论其中三种。I型胶原蛋白存在于肌腱、皮肤和许多其他器官中，例如眼睛。III型主要存在于血管中，但也存在于其他中胚层起源的组织中，IV型存在于基底膜中。为了阐明胶原蛋白类型在眼部结构中的精确分布，对正常人眼进行了免疫组织化学研究。还分析了作为胶原蛋白特征的氨基酸脯氨酸、羟脯氨酸和羟赖氨酸。在筛板、小梁网和筛板后视神经中发现了I型、III型和IV型胶原蛋白。相比之下，巩膜中仅发现I型。
