Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Institute for Innovation in Digital Healthcare, Yonsei University, Seoul, 06237, Republic of Korea.
Lipids Health Dis. 2023 Jul 4;22(1):94. doi: 10.1186/s12944-023-01857-5.
Small dense low-density lipoprotein cholesterol (sdLDL-C) is the lipoprotein marker among the various lipoproteins that is most strongly related to atherosclerosis. Insulin resistance (IR) can alter lipid metabolism, and sdLDL-C is characteristic of diabetic dyslipidemia. Therefore, this study sought to inspect the relationship between the triglyceride-glucose (TyG) index and mean low-density lipoprotein (LDL) particle size.
In this study, a total of 128 adults participated. The correlation coefficients between various lipoproteins and the TyG index were compared using Steiger's Z test and the Spearman correlation. The independent link between the TyG index and mean LDL particle size was demonstrated by multiple linear regression analysis. To identify the TyG index cutoff value for the predominance of sdLDL particles, receiver operating characteristic curves were plotted.
Mean LDL particle size correlated more strongly with the TyG index than did very low-density lipoprotein, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. Regression analysis demonstrated that mean LDL particle size had a strong association with the TyG index (β coefficient = -0.038, P-value < 0.001). The TyG index optimal cutoff value for sdLDL particle predominance and the corresponding area under the curve (standard error: 0.028, 95% confidence interval: 0.842-0.952) were 8.72 and 0.897, respectively, which were close to the cutoff value of diabetes risk in Koreans.
Mean LDL particle size is more strongly correlated with the TyG index than do other lipid parameters. After correcting for confounding variables, mean LDL particle size is independently linked with the TyG index. The study indicates that the TyG index is strongly related to atherogenic sdLDL particles predominance.
小而密的低密度脂蛋白胆固醇（sdLDL-C）是各种脂蛋白中与动脉粥样硬化关系最密切的脂蛋白标志物。胰岛素抵抗（IR）会改变脂质代谢，sdLDL-C 是糖尿病血脂异常的特征。因此，本研究旨在观察甘油三酯-葡萄糖（TyG）指数与平均低密度脂蛋白（LDL）颗粒大小之间的关系。
本研究共纳入 128 名成年人。采用 Steiger 的 Z 检验和 Spearman 相关比较各种脂蛋白与 TyG 指数的相关系数。采用多元线性回归分析证明 TyG 指数与平均 LDL 颗粒大小之间的独立联系。为了确定 TyG 指数对 sdLDL 颗粒优势的截断值，绘制了受试者工作特征曲线。
平均 LDL 颗粒大小与 TyG 指数的相关性强于极低密度脂蛋白、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇。回归分析表明，平均 LDL 颗粒大小与 TyG 指数有很强的相关性（β系数=-0.038，P 值<0.001）。TyG 指数对 sdLDL 颗粒优势的最佳截断值及其相应曲线下面积（标准误：0.028，95%置信区间：0.842-0.952）分别为 8.72 和 0.897，接近韩国人糖尿病风险的截断值。
平均 LDL 颗粒大小与 TyG 指数的相关性强于其他脂质参数。在排除混杂因素后，平均 LDL 颗粒大小与 TyG 指数独立相关。研究表明，TyG 指数与致动脉粥样硬化的 sdLDL 颗粒优势密切相关。
