Bodis-Wollner I, Marx M S, Mitra S, Bobak P, Mylin L, Yahr M
Department of Neurology, Mount Sinai School of Medicine of the City University of New York, NY.
Brain. 1987 Dec;110 ( Pt 6):1675-98. doi: 10.1093/brain/110.6.1675.
Flicker sensitivity and spatial contrast sensitivity (CS) were examined in a total of 99 patients with Parkinson's disease (PD). All patients were undergoing treatment with dopaminergic agents. Specific losses in sensitivity observed in PD were (1) a loss in flicker sensitivity which was most pronounced around the peak of the function (8 Hz) and (2) a loss near the peak of the spatial CS curve, often with no noticeable low frequency attenuation. Several PD patients affected by the 'on-off' syndrome were tested in both 'on' and 'off' phases, and the results show that the CS function switches in parallel with motor symptoms of the disease. These data suggest that not only is the visual system affected in PD, but that dopamine may have an essential role in receptive field organization in human vision.
对总共99例帕金森病（PD）患者进行了闪烁敏感度和空间对比敏感度（CS）检测。所有患者均在接受多巴胺能药物治疗。在帕金森病中观察到的敏感度特异性损失为：（1）闪烁敏感度损失，在功能峰值（8赫兹）附近最为明显；（2）空间CS曲线峰值附近的损失，低频衰减通常不明显。对几名受“开-关”综合征影响的帕金森病患者在“开”和“关”阶段均进行了测试，结果表明CS功能与疾病的运动症状平行变化。这些数据表明，帕金森病不仅会影响视觉系统，而且多巴胺可能在人类视觉的感受野组织中起重要作用。
