Department of Pediatrics, Division of Neonatology, University of Alabama, Birmingham, United Kingdom.
Department of Pediatrics, Division of Neonatology, University of Alabama, Birmingham, United Kingdom.
Semin Perinatol. 2021 Oct;45(6):151454. doi: 10.1016/j.semperi.2021.151454. Epub 2021 Jun 18.
The recently recognized connection between the gut microbiota and pulmonary disease has been termed the gut-lung axis. However, broader connections link the gut and the lungs and these organ systems are tightly interrelated in both homeostasis and disease. This concept is often ignored in the compartmentalized treatment of pulmonary or gastrointestinal disease. In newborns, the most severe gastrointestinal complication of prematurity, necrotizing enterocolitis, and the most severe pulmonary complication, bronchopulmonary dysplasia, both produce significant systemic morbidity. In this review, we highlight the often neglected pathophysiology of the gut-lung axis contributes to increased risk of bronchopulmonary dysplasia in premature infants with necrotizing enterocolitis.
最近发现肠道微生物群与肺部疾病之间存在关联，这一关联被称为“肠-肺轴”。然而，更广泛的联系将肠道和肺部联系在一起，在稳态和疾病中，这些器官系统紧密相关。在肺部或胃肠道疾病的分科治疗中，这一概念经常被忽视。在新生儿中，最严重的胃肠道并发症——早产儿坏死性小肠结肠炎和最严重的肺部并发症——支气管肺发育不良，都会导致严重的全身发病率。在这篇综述中，我们强调了肠-肺轴被忽视的病理生理学，这增加了患有坏死性小肠结肠炎的早产儿患支气管肺发育不良的风险。
