Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia.
Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia.
J Mycol Med. 2021 Dec;31(4):101174. doi: 10.1016/j.mycmed.2021.101174. Epub 2021 Jul 5.
Mucormycosis is a life-threatening disease responsible for a high mortality rate. The disease usually affects immuno-compromised patients. While all sites might be involved, gastrointestinal disease is rare, occurring for 5% to 13% of all mucormycosis cases. We report herein the fifth case of splenic and gastric mucormycosis revealed after gastric perforation and the first case occurring among an immuno-competent patient, and we review all reported cases of splenic mucormycosis by searching PubMed publications till October 2020. The literature search yielded 27 cases of splenic mucormycosis including our case. The majority of the cases had underlying immuno-compromised conditions, except for 6 cases, including ours. A male predominance was noted (22 cases). Involvement of the spleen and the stomach was rare, occurring among four immuno-compromised patients. The outcome was death in more than half of the cases. Splenic and gastric mucormycosis is a rare disease. The diagnosis of splenic mucormycosis should be considered in front of splenic lesions suggesting abscess or infarction, especially among immuno-compromised patients.
毛霉菌病是一种危及生命的疾病,死亡率很高。该疾病通常影响免疫功能低下的患者。虽然所有部位都可能受累,但胃肠道疾病很少见,占所有毛霉菌病病例的 5%至 13%。我们在此报告第五例胃穿孔后发生的脾和胃毛霉菌病,也是首例发生于免疫功能正常患者的病例,并通过检索 2020 年 10 月之前在 PubMed 上发表的文献,对所有报道的脾毛霉菌病病例进行了回顾。文献检索共获得 27 例脾毛霉菌病病例,包括我们的病例。除了 6 例,大多数病例都有潜在的免疫功能低下,包括我们的病例。男性居多(22 例)。脾和胃受累罕见,发生于 4 例免疫功能低下的患者中。超过一半的病例结局为死亡。脾和胃毛霉菌病是一种罕见疾病。在免疫功能低下的患者中,特别是在提示脓肿或梗死的脾病变前,应考虑脾毛霉菌病的诊断。