血液中毛霉目PCR检测作为侵袭性胃肠道毛霉病的早期标志物可能会减少治疗延迟：一例报告
Mucorales PCR in blood as an early marker of invasive gastrointestinal mucormycosis might decrease the delay in treatment: A case report.
作者信息
Aerts Robina, De Vlieger Greet, Debaveye Yves, Topal Halit, De Hertogh Gert, Lagrou Katrien, Maertens Johan
机构信息
Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium.
Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
出版信息
Med Mycol Case Rep. 2022 Dec 15;39:8-12. doi: 10.1016/j.mmcr.2022.12.001. eCollection 2023 Mar.
We describe the fatal case of a patient with gastric perforation due to ischemia and necrosis of the stomach secondary to generalized vascular thrombosis following allogeneic hematopoietic cell transplantation. Histopathological examination of the resected stomach, spleen and omentum unexpectedly showed fungal hyphae suggestive of invasive mucormycosis. We retrospectively performed Mucorales PCR (MucorGenius®, PathoNostics, Maastricht, The Netherlands) in blood and tissue samples of this patient. The PCR was positive 16 days before time of death and 9 days before abdominal pain.
我们描述了一例异基因造血细胞移植后因全身血管血栓形成继发胃缺血坏死导致胃穿孔的致命病例。对切除的胃、脾脏和大网膜进行组织病理学检查，意外发现提示侵袭性毛霉菌病的真菌菌丝。我们对该患者的血液和组织样本进行了回顾性毛霉目PCR检测（MucorGenius®，PathoNostics，荷兰马斯特里赫特）。PCR检测在死亡前16天和腹痛前9天呈阳性。
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