Department of Hematology, Hakodate Municipal Hospital, Japan.
Intern Med. 2022 Jan 15;61(2):237-240. doi: 10.2169/internalmedicine.7758-21. Epub 2021 Jul 17.
A 71-year-old woman was admitted for the treatment of diffuse large B-cell lymphoma of the ileum. She had been taking lansoprazole but was switched to vonoprazan due to epigastric discomfort. Three weeks after starting vonoprazan intake, she had a convulsive seizure, and a blood test showed hypomagnesiemia. The cause of hypomagnesemia was considered to be malabsorption of magnesium from the intestinal tract associated with vonoprazan. After discontinuation of vonoprazan, the magnesium level quickly recovered, and the seizures did not relapse. It is important to consider the risk of hypomagnesemia in patients taking vonoprazan, even for a short period of time.
一位 71 岁女性因回肠弥漫性大 B 细胞淋巴瘤入院治疗。她一直在服用兰索拉唑，但由于上腹部不适，改用沃诺拉赞。开始服用沃诺拉赞 3 周后，她发生了抽搐性癫痫发作，血液检查显示低镁血症。低镁血症的原因被认为是与沃诺拉赞相关的肠道镁吸收不良。停用沃诺拉赞后，镁水平迅速恢复，癫痫未再发作。即使服用时间很短，也应考虑服用沃诺拉赞的患者发生低镁血症的风险。
