DNA修复基因的拷贝数分析揭示了聚（ADP-核糖）聚合酶（PARP）在树木长寿中的作用。

Copy number analyses of DNA repair genes reveal the role of poly(ADP-ribose) polymerase (PARP) in tree longevity.

作者信息

Aoyagi Blue Yuta, Kusumi Junko, Satake Akiko

机构信息

Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka, Fukuoka, 819-0395, Japan.

Department of Environmental Changes, Faculty of Social and Cultural Studies, Kyushu University, 744 Motooka, Fukuoka819-0395, Japan.

出版信息

iScience. 2021 Jun 24;24(7):102779. doi: 10.1016/j.isci.2021.102779. eCollection 2021 Jul 23.

Long-lived organisms are exposed to the risk of accumulating mutations due to DNA damage. Previous studies in animals have revealed the positive relationship between the copy number of DNA repair genes and longevity. However, the role of DNA repair in the lifespan of plants remains poorly understood. Using the recent accumulation of the complete genome sequences of diverse plant species, we performed systematic comparative analyses of the copy number variations of DNA repair genes in 61 plant species with different lifespans. Among 121 DNA repair gene families, gene family was identified as a unique gene that exhibits significant expansion in trees compared to annual and perennial herbs. Among three paralogs of plant , showed a close association with growth rate. PARPs catalyze poly(ADP-ribosyl)ation and play pivotal roles in DNA repair and antipathogen defense. Our study suggests the conserved role of PARPs in longevity between plants and animals.

长寿生物由于DNA损伤而面临积累突变的风险。先前对动物的研究揭示了DNA修复基因拷贝数与寿命之间的正相关关系。然而，DNA修复在植物寿命中的作用仍知之甚少。利用近期多种植物物种完整基因组序列的积累，我们对61种不同寿命的植物物种中DNA修复基因的拷贝数变异进行了系统的比较分析。在121个DNA修复基因家族中，有一个基因家族被鉴定为与一年生和多年生草本植物相比，在树木中显著扩增的独特基因。在植物的三个旁系同源物中，其中一个与生长速率密切相关。聚（ADP-核糖）聚合酶（PARP）催化聚（ADP-核糖基）化反应，并在DNA修复和抗病原体防御中起关键作用。我们的研究表明PARP在植物和动物寿命方面具有保守作用。