Department of Midwifery, University of West Attica, Athens, Greece.
2nd Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, "Aretaieio" University Hospital, Athens, Greece.
Bosn J Basic Med Sci. 2022 Feb 1;22(1):46-53. doi: 10.17305/bjbms.2021.6205.
Neonatal brain injury is a serious adverse outcome of prematurity. Early detection of high risk premature neonates to develop neonatal brain injury is not currently feasible. The predictive value of many biomarkers has been tested, but none is used currently in clinical practice. The purpose of this study was to determine the levels and predictive value of serum glial fibrillary acidic protein (GFAP) in a prospective longitudinal case-control study during the first three days of life in premature neonates (<34 weeks of gestation) that later developed either intraventricular hemorrhage or periventricular leukomalacia. Each case (n=29) was matched according to birth weight and gestational age to one neonate with normal head ultrasound scans. No significant difference on GFAP levels was observed between the groups. Nevertheless, neonates with brain injury presented more frequently GFAP levels above the lowest detection limit (0.056 ng/ml) and this trend was significantly different during all days. The effectiveness of GFAP as an early biomarker of neonatal brain injury in premature neonates seems to be limited.
新生儿脑损伤是早产儿的严重不良后果。目前还不可能早期发现高危早产儿发生新生儿脑损伤。许多生物标志物的预测价值已经过测试，但目前没有一种在临床实践中使用。本研究的目的是在出生后第 1 至 3 天的前瞻性纵向病例对照研究中，确定血清神经胶质纤维酸性蛋白 (GFAP) 在早产儿(<34 周妊娠)中的水平和预测价值，这些早产儿后来发生脑室出血或脑室周围白质软化。每个病例 (n=29) 均根据出生体重和胎龄与正常头超声扫描的新生儿相匹配。两组间 GFAP 水平无显著差异。然而，脑损伤患儿的 GFAP 水平更频繁地高于最低检测限 (0.056ng/ml)，并且这种趋势在所有天数均显著不同。GFAP 作为早产儿新生儿脑损伤的早期生物标志物的有效性似乎有限。
