胶质纤维酸性蛋白作为全身冷却治疗新生儿缺氧缺血性脑病的生物标志物。
Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling.
机构信息
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Am J Obstet Gynecol. 2011 Sep;205(3):251.e1-7. doi: 10.1016/j.ajog.2011.06.025. Epub 2011 Jun 15.
Abstract
OBJECTIVE
Glial fibrillary acidic protein (GFAP) is specific to astrocytes in the central nervous system. We hypothesized that serum GFAP would be increased in neonates with hypoxic-ischemic encephalopathy (HIE) treated with whole-body cooling.
STUDY DESIGN
We measured GFAP at birth and daily for up to 7 days for neonates in the intensive care unit. We compared neonates with HIE treated with whole-body cooling to gestational age-matched controls without neurological injury and neonates with HIE by brain abnormalities on magnetic resonance imaging (MRI).
RESULTS
Neonates with HIE had increased GFAP levels compared with controls. Neonates with HIE and abnormal brain imaging had elevated GFAP levels compared with neonates with HIE and normal imaging.
CONCLUSION
Serum GFAP levels during the first week of life were increased in neonates with HIE and were predictive of brain injury on MRI. Biomarkers such as GFAP could help triage neonates with HIE to treatment, measure treatment efficacy, and provide prognostic information.
摘要
目的
胶质纤维酸性蛋白（GFAP）是中枢神经系统星形胶质细胞的特异性标志物。我们假设全身冷却治疗的缺氧缺血性脑病（HIE）新生儿血清 GFAP 会升高。
研究设计
我们在重症监护病房测量了新生儿出生时和出生后 7 天内的 GFAP。我们将接受全身冷却治疗的 HIE 新生儿与无神经损伤的胎龄匹配对照组以及 MRI 显示有脑异常的 HIE 新生儿进行比较。
结果
与对照组相比，HIE 新生儿的 GFAP 水平升高。与 HIE 且 MRI 正常的新生儿相比，HIE 且 MRI 异常的新生儿 GFAP 水平升高。
结论
HIE 新生儿在生命的第一周内血清 GFAP 水平升高，并且可预测 MRI 上的脑损伤。GFAP 等生物标志物可帮助对 HIE 新生儿进行治疗分类、测量治疗效果并提供预后信息。
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