The Gene rs1799750 Polymorphism Is Associated with Breast Cancer Risk.

Numerous studies investigating an association between the matrix metalloproteinase-1 () gene rs1799750 polymorphism and breast cancer (BC) risk have reported inconsistent results. Therefore, this meta-analysis was undertaken to obtain a more precise estimate of the possible association between this genetic locus and BC susceptibility. Eight eligible studies involving 3439 cases and 3517 controls were identified by searching the PubMed, Google, CNKI, and EMBASE databases systematically through October 1, 2020. The rs1799750 polymorphism was associated with a reduced BC risk in the overall study population under the heterozygous model. Stratification analyses indicated that this association is strong in Asians. There is evidence of an association between the rs1799750 polymorphism and BC susceptibility, viewed as a decreased risk factor for BC. More extensive studies with more diverse ethnic populations are necessary to confirm these findings.