Department of Laboratory Medicine, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China.
Genet Test Mol Biomarkers. 2021 Jul;25(7):496-503. doi: 10.1089/gtmb.2021.0016.
Numerous studies investigating an association between the matrix metalloproteinase-1 () gene rs1799750 polymorphism and breast cancer (BC) risk have reported inconsistent results. Therefore, this meta-analysis was undertaken to obtain a more precise estimate of the possible association between this genetic locus and BC susceptibility. Eight eligible studies involving 3439 cases and 3517 controls were identified by searching the PubMed, Google, CNKI, and EMBASE databases systematically through October 1, 2020. The rs1799750 polymorphism was associated with a reduced BC risk in the overall study population under the heterozygous model. Stratification analyses indicated that this association is strong in Asians. There is evidence of an association between the rs1799750 polymorphism and BC susceptibility, viewed as a decreased risk factor for BC. More extensive studies with more diverse ethnic populations are necessary to confirm these findings.
许多研究调查基质金属蛋白酶-1 () 基因 rs1799750 多态性与乳腺癌 (BC) 风险之间的关联，但其结果并不一致。因此，进行了这项荟萃分析，以更准确地评估该遗传位点与 BC 易感性之间的可能关联。 通过系统搜索 PubMed、Google、CNKI 和 EMBASE 数据库，截至 2020 年 10 月 1 日，共确定了 8 项符合条件的研究，涉及 3439 例病例和 3517 例对照。 rs1799750 多态性与总体研究人群的 BC 风险降低相关，在杂合子模型下具有统计学意义。分层分析表明，这种关联在亚洲人群中更强。 有证据表明 rs1799750 多态性与 BC 易感性之间存在关联，被视为 BC 的一个降低风险因素。需要更多具有不同种族人群的广泛研究来证实这些发现。
