基质金属蛋白酶-1（MMP-1）rs1799750基因多态性与鼻咽癌（NPC）风险相关。

Matrix metalloproteinase-1 (MMP-1) rs1799750 polymorphism is associated with nasopharyngeal carcinoma (NPC) risk.

作者信息

Cao L, Li P, Dong L

机构信息

E.N.T. Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, Jilin, China.

出版信息

Cell Mol Biol (Noisy-le-grand). 2017 Oct 31;63(10):1-3. doi: 10.14715/cmb/2017.63.10.1.

DOI:10.14715/cmb/2017.63.10.1

PMID:29096757

Abstract

A few studies suggested that matrix metalloproteinase 1 (MMP-1) rs1799750 polymorphism was associated with nasopharyngeal carcinoma (NPC) risk. However, other studies did not confirm this result. Thus, we did this meta-analysis to evaluate the association between MMP-1 rs1799750 polymorphism and NPC risk. We searched PubMed and EMBASE. Five studies with 1497 cases and 1643 controls were included in this meta-analysis. Subjects with MMP-1 rs1799750 polymorphism had an decreased NPC risk (OR = 0.79; 95%CI, 0.69-0.91; P = 0.0007; I2 = 70%). In the subgroup analysis by smoking, a marginally significant association was found in non-smokers (OR = 0.73, 95% CI 0.52 - 1.04, P = 0.08; I2 = 0%) but not smokers (OR = 0.59, 95% CI 0.24 - 1.42, P = 0.24; I2 = 83%). In conclusion, this meta-analysis showed that MMP-1 rs1799750 polymorphism was significantly associated with NPC risk.

摘要

一些研究表明，基质金属蛋白酶1（MMP - 1）rs1799750多态性与鼻咽癌（NPC）风险相关。然而，其他研究并未证实这一结果。因此，我们进行了这项荟萃分析，以评估MMP - 1 rs1799750多态性与NPC风险之间的关联。我们检索了PubMed和EMBASE。五项研究共纳入1497例病例和1643例对照，进行了这项荟萃分析。具有MMP - 1 rs1799750多态性的受试者患NPC的风险降低（OR = 0.79；95%CI，0.69 - 0.91；P = 0.0007；I2 = 70%）。在按吸烟情况进行的亚组分析中，在不吸烟者中发现了边缘显著的关联（OR = 0.73，95%CI 0.52 - 1.04，P = 0.08；I2 = 0%），但吸烟者中未发现（OR = 0.59，95%CI 0.24 - 1.42，P = 0.24；I2 = 83%）。总之，这项荟萃分析表明，MMP - 1 rs1799750多态性与NPC风险显著相关。