He Miao, Wang Wei, Han Xiao, Huang Wenyong
a Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology , Sun Yat-Sen University , Guangzhou , China.
Ophthalmic Genet. 2017 May-Jun;38(3):211-216. doi: 10.1080/13816810.2016.1193877. Epub 2016 Jul 18.
Several studies indicated that -1607 1G/2G (rs1799750) polymorphism in matrix metalloproteinase-1 (MMP-1) promoter was correlated with glaucoma susceptibility, but the results remain controversial. We performed a meta-analysis to assess whether rs1799750 confers glaucoma risk.
Eligible studies were retrieved by systematically searching Pubmed, Embase, Web of Science, and Chinese Biomedical database. The degree of correlation was expressed as odds ratios (ORs) and 95% confidence interval (CI). The measurements were pooled by fixed effect model or random effect model.
This meta-analysis included five case-control studies involving 1261 patients with glaucoma and 1089 controls. The pooled results showed a significant association between rs1799750 and glaucoma under the homozygote (OR = 1.71, 95% CI 1.12-2.62, p = 0.014), recessive (OR = 1.64, 95% CI 1.20-2.25, p = 0.002), and allelic (OR = 1.35, 95% CI 1.05-1.72, p = 0.017) models. Subgroup analyses showed that the rs1799750 was significantly associated with primary angle closure glaucoma under homozygote (OR = 2.23, 95% CI 1.03-4.83, p = 0.043) and allelic (OR = 1.61, 95% CI 1.07-2.42, P = 0.021) models, while it was significantly associated with primary open angle glaucoma (OR = 1.64, 95% CI 1.05-2.56, p = 0.030) and exfoliation glaucoma (OR = 1.42, 95% CI 1.02-1.97, p = 0.036) under recessive models. No evidence of publication bias was detected.
Meta-analysis of existing data showed that rs1799750 may affect individual susceptibility to glaucoma. Nevertheless, more studies with large sample size and various ethnicities are warranted in light of the limited studies.
多项研究表明，基质金属蛋白酶-1（MMP-1）启动子中的-1607 1G/2G（rs1799750）多态性与青光眼易感性相关，但结果仍存在争议。我们进行了一项荟萃分析，以评估rs1799750是否会增加患青光眼的风险。
通过系统检索PubMed、Embase、Web of Science和中国生物医学数据库，获取符合条件的研究。相关性程度以比值比（OR）和95%置信区间（CI）表示。测量结果采用固定效应模型或随机效应模型进行汇总。
这项荟萃分析纳入了五项病例对照研究，共涉及1261例青光眼患者和1089例对照。汇总结果显示，在纯合子（OR = 1.71，95% CI 1.12 - 2.62，p = 0.014）、隐性（OR = 1.64，95% CI 1.20 - 2.25，p = 0.002）和等位基因（OR = 1.35，95% CI 1.05 - 1.72，p = 0.017）模型下，rs1799750与青光眼之间存在显著关联。亚组分析表明，在纯合子（OR = 2.23，95% CI 1.03 - 4.83，p = 0.043）和等位基因（OR = 1.61，95% CI 1.07 - 2.42，P = 0.021）模型下，rs1799750与原发性闭角型青光眼显著相关，而在隐性模型下，它与原发性开角型青光眼（OR = 1.64，95% CI 1.05 - 2.56，p = 0.030）和剥脱性青光眼（OR = 1.42，95% CI 1.02 - 1.97，p = 0.036）显著相关。未检测到发表偏倚的证据。
对现有数据的荟萃分析表明，rs1799750可能会影响个体对青光眼的易感性。然而，鉴于研究有限，仍需要更多大样本量和不同种族的研究。
