IDO in Colorectal Tumorigenesis: Involvement of Immune Tolerance and Significance in Prevention and Therapy.
作者信息
Tang Shunan, Wang Jingya, Yu Siwang
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, China.
State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, China.
出版信息
Cell Mol Gastroenterol Hepatol. 2021;12(4):1503-1504. doi: 10.1016/j.jcmgh.2021.06.021. Epub 2021 Jul 17.
Abstract
摘要
相似文献
1
IDO in Colorectal Tumorigenesis: Involvement of Immune Tolerance and Significance in Prevention and Therapy.吲哚胺 2,3-双加氧酶在结直肠癌发生中的作用：免疫耐受的参与及在预防和治疗中的意义
Cell Mol Gastroenterol Hepatol. 2021;12(4):1503-1504. doi: 10.1016/j.jcmgh.2021.06.021. Epub 2021 Jul 17.
2
Prevention and therapy of colorectal cancer.结直肠癌的预防与治疗。
Med Clin North Am. 2005 Jan;89(1):85-110, viii. doi: 10.1016/j.mcna.2004.08.003.
3
Carcinogenesis, prevention and treatment of colorectal cancer--State of the Art 2012. Introduction.结直肠癌的致癌作用、预防与治疗——2012年最新进展。引言。
Dig Dis. 2012;30 Suppl 2:1. doi: 10.1159/000342049. Epub 2012 Nov 23.
4
Colorectal cancer: Calcineurin drives CRC tumorigenesis.结直肠癌：钙调神经磷酸酶驱动结直肠癌的肿瘤发生。
Nat Rev Gastroenterol Hepatol. 2016 May;13(5):249. doi: 10.1038/nrgastro.2016.65. Epub 2016 Apr 14.
5
Metabolic reprogramming links chronic intestinal inflammation and the oncogenic transformation in colorectal tumorigenesis.代谢重编程将慢性肠道炎症与结直肠肿瘤发生中的致癌转化联系起来。
Cancer Lett. 2019 May 28;450:123-131. doi: 10.1016/j.canlet.2019.02.045. Epub 2019 Mar 7.
6
Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy.结直肠癌中的Toll样受体信号传导：从致癌作用到癌症治疗
World J Gastroenterol. 2014 Dec 21;20(47):17699-708. doi: 10.3748/wjg.v20.i47.17699.
7
The TNF family member APRIL promotes colorectal tumorigenesis.APRIL 是 TNF 家族的一员，促进结直肠肿瘤的发生。
Cell Death Differ. 2012 Nov;19(11):1826-35. doi: 10.1038/cdd.2012.68. Epub 2012 Jun 15.
8
Circadian clock circuitry in colorectal cancer.结直肠癌中的昼夜节律时钟机制
World J Gastroenterol. 2014 Apr 21;20(15):4197-207. doi: 10.3748/wjg.v20.i15.4197.
9
The role of interleukin-17A in colorectal tumorigenesis.白细胞介素-17A 在结直肠肿瘤发生中的作用。
Cancer Biother Radiopharm. 2013 Jul-Aug;28(6):429-32. doi: 10.1089/cbr.2012.1396. Epub 2013 May 23.
10
Fusobacterium nucleatum: an emerging bug in colorectal tumorigenesis.具核梭杆菌：结直肠癌发生过程中一个新出现的问题。
Eur J Cancer Prev. 2015 Sep;24(5):373-85. doi: 10.1097/CEJ.0000000000000116.
引用本文的文献
1
Harnessing IDO inhibitors to optimize cancer immunotherapy.利用吲哚胺2,3-双加氧酶抑制剂优化癌症免疫疗法。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jul 17. doi: 10.1007/s00210-025-04445-9.
2
Evaluation of Indoleamine 2,3-Dioxygenase (IDO) Expression in Osteosarcoma: Insights From a 10-Year Retrospective Cohort.骨肉瘤中吲哚胺2,3-双加氧酶（IDO）表达的评估：来自一项10年回顾性队列研究的见解
Onco Targets Ther. 2025 Mar 17;18:367-377. doi: 10.2147/OTT.S494899. eCollection 2025.
3
Spatial distribution pattern of immune cells is associated with patient prognosis in colorectal cancer.免疫细胞的空间分布模式与结直肠癌患者的预后相关。
J Transl Med. 2024 Jul 1;22(1):606. doi: 10.1186/s12967-024-05418-x.
4
Pathways and molecules for overcoming immunotolerance in metastatic gastrointestinal tumors.转移性胃肠道肿瘤中克服免疫耐受的途径和分子
Front Immunol. 2024 Apr 5;15:1359914. doi: 10.3389/fimmu.2024.1359914. eCollection 2024.
5
Tryptophan Modulation in Cancer-Associated Cachexia Mouse Models.色氨酸调节与癌症相关恶病质的小鼠模型。
Int J Mol Sci. 2023 Aug 21;24(16):13005. doi: 10.3390/ijms241613005.
6
Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting.结直肠癌浸润调节性 T 细胞：功能异质性、代谢适应及治疗靶点。
Front Immunol. 2022 Jul 8;13:903564. doi: 10.3389/fimmu.2022.903564. eCollection 2022.
本文引用的文献
1
Blockade of IDO-Kynurenine-AhR Axis Ameliorated Colitis-Associated Colon Cancer via Inhibiting Immune Tolerance.吲哚胺 2,3-双加氧酶-犬尿氨酸-芳香烃受体轴的阻断通过抑制免疫耐受改善结肠炎相关结直肠癌。
Cell Mol Gastroenterol Hepatol. 2021;12(4):1179-1199. doi: 10.1016/j.jcmgh.2021.05.018. Epub 2021 Jun 1.
2
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
3
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy.犬尿酸途径在每种癌症中的足迹：化疗的新靶点。
Eur J Pharmacol. 2021 Apr 5;896:173921. doi: 10.1016/j.ejphar.2021.173921. Epub 2021 Jan 30.
4
Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in Mice.芳香烃受体缺失促进小鼠结肠肿瘤发生。
Mol Cancer Res. 2021 May;19(5):771-783. doi: 10.1158/1541-7786.MCR-20-0789. Epub 2021 Jan 25.
5
Detrimental activation of AhR pathway in cancer: an overview of therapeutic strategies.芳烃受体（AhR）通路在癌症中的有害激活：治疗策略概述。
Curr Opin Immunol. 2021 Jun;70:15-26. doi: 10.1016/j.coi.2020.12.003. Epub 2021 Jan 8.
6
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.阻断 AHR 可限制由 L-犬尿酸诱导的 Treg-巨噬细胞抑制轴。
Nat Commun. 2020 Aug 11;11(1):4011. doi: 10.1038/s41467-020-17750-z.
7
Colorectal cancer statistics, 2020.2020 年结直肠癌统计数据。
CA Cancer J Clin. 2020 May;70(3):145-164. doi: 10.3322/caac.21601. Epub 2020 Mar 5.
8
Immunotherapy in colorectal cancer: rationale, challenges and potential.结直肠癌的免疫治疗：原理、挑战与潜能。
Nat Rev Gastroenterol Hepatol. 2019 Jun;16(6):361-375. doi: 10.1038/s41575-019-0126-x.
9
IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis.IDO1 和犬尿氨酸途径代谢物激活肿瘤性结肠上皮中的 PI3K-Akt 信号通路，促进癌细胞增殖并抑制细胞凋亡。
Cancer Res. 2019 Mar 15;79(6):1138-1150. doi: 10.1158/0008-5472.CAN-18-0668. Epub 2019 Jan 24.
10
Companies Scaling Back IDO1 Inhibitor Trials.药企缩减 IDO1 抑制剂临床试验。
Cancer Discov. 2018 Jul;8(7):OF5. doi: 10.1158/2159-8290.CD-ND2018-007. Epub 2018 May 30.
Zotero 插件