Bashir Arif, Miskeen Abid Y, Bhat Ashaqullah, Fazili Khalid M, Ganai Bashir A
aDepartment of Biotechnology bCentre of Research for Development, University of Kashmir, Srinagar, J&K cDepartment of Human Genetics, Punjabi University, Patiala, Punjab, India.
Eur J Cancer Prev. 2015 Sep;24(5):373-85. doi: 10.1097/CEJ.0000000000000116.
The human intestinal microbiota is a plethora of diverse microbial species, wherein certain bacteria considered as driver bacteria with procarcinogenic features contribute directly toward colonic epithelium cell damage to initiate colorectal carcinogenesis. However, some bacteria, in particular Fusobacterium nucleatum, which is otherwise a normal resident of the oral microflora and a relatively poor colonizer of the healthy gut, have also been considered to play a role in the development of colorectal cancer. Many studies have reported that F. nucleatum is associated with colorectal adenomas and advanced-stage colorectal cancer, but its precise role in the early stages of colorectal tumorigenesis is poorly understood. Here, we review some of the important features of F. nucleatum, its association with inflammatory bowel disease, modulation of the tumor-immune microenvironment, and E-cadherin/β-catenin signaling.
人类肠道微生物群是大量多样的微生物物种，其中某些被视为具有促癌特征的驱动菌的细菌直接导致结肠上皮细胞损伤，从而引发结直肠癌。然而，一些细菌，特别是具核梭杆菌，它原本是口腔微生物群的正常居民，在健康肠道中相对难以定殖，但也被认为在结直肠癌的发展中起作用。许多研究报告称，具核梭杆菌与结直肠腺瘤和晚期结直肠癌有关，但其在结直肠癌发生早期的确切作用尚不清楚。在这里，我们综述了具核梭杆菌的一些重要特征、它与炎症性肠病的关联、对肿瘤免疫微环境的调节以及E-钙黏蛋白/β-连环蛋白信号传导。
