系统性硬化症患者性功能障碍的患病率及相关危险因素：一项系统综述。
Prevalence of Sexual Dysfunction in People With Systemic Sclerosis and the Associated Risk Factors: A Systematic Review.
作者信息
Gao Rui, Qing Pingying, Sun Xiaochi, Zeng Xun, Hu Xiao, Zhang Sirui, Yang Yihong, Qin Lang
机构信息
The Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China; West China School of Medicine, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.
出版信息
Sex Med. 2021 Aug;9(4):100392. doi: 10.1016/j.esxm.2021.100392. Epub 2021 Jul 16.
INTRODUCTION
The association between systemic sclerosis (SSc) and sexual dysfunction was controversial.
AIM
To explore the impacts of SSc on sexual function, the prevalence of sexual dysfunction in patients with SSc and associated risk factors.
METHODS
A systematic review of all published studies was performed. Studies exploring the association between SSc and sexual function were retrieved from PubMed, Web of Science, and EBSCO. All retrieved papers were selected according to the inclusion and exclusion criteria.
MAIN OUTCOME MEASURE
The impacts of SSc on sexual function, the prevalence of sexual dysfunction in males and females with SSc and associated risk factors.
RESULTS
A total 12 studies were included in this study. The prevalence of sexual dysfunction in SSc males and SSc females were 76.9-81.4% and 46.7-86.6%, respectively. But the direct impacts of SSc on sexual function were controversial. EULAR SSc activity score ≥3, the number of complications ≥2, and the presence of anticardiolipin antibody and anti U1 ribonucleoprotein antibody in males and resistive index (RI) and the systolic/diastolic (S/D) ratio of clitoral blood in females have potential to be SSc-specific risk factors for sexual dysfunction.
CLINICAL IMPLICATIONS
Clinicians need to pay more attention to the impacts of SSc on sexual function of patients especially in those with risk factors.
STRENGTHS & LIMITATIONS: Systematically explored the prevalence of sexual dysfunction in SSc males and females, and the risk factors of sexual dysfunction for SSc were explored innovatively. However, there were some limitations in included studies prevented exploring the impacts of SSc on sexual function deeply.
CONCLUSION
Sexual dysfunction may be an important symptom of SSc, many risk factors may be associated with sexual dysfunction in males and females with SSc. Gao R, Qing P, Sun X, et al. Prevalence of Sexual Dysfunction in People With Systemic Sclerosis and the Associated Risk Factors: A Systematic Review. Sex Med 2021;9:100392.
引言
系统性硬化症（SSc）与性功能障碍之间的关联存在争议。
目的
探讨SSc对性功能的影响、SSc患者性功能障碍的患病率及相关危险因素。
方法
对所有已发表的研究进行系统综述。从PubMed、科学网和EBSCO检索探讨SSc与性功能之间关联的研究。所有检索到的论文均根据纳入和排除标准进行筛选。
主要观察指标
SSc对性功能的影响、SSc男性和女性性功能障碍的患病率及相关危险因素。
结果
本研究共纳入12项研究。SSc男性和女性性功能障碍的患病率分别为76.9 - 81.4%和46.7 - 86.6%。但SSc对性功能的直接影响存在争议。欧洲抗风湿病联盟（EULAR）SSc活动评分≥3、并发症数量≥2、男性抗心磷脂抗体和抗U1核糖核蛋白抗体的存在以及女性阴蒂血液的阻力指数（RI）和收缩压/舒张压（S/D）比值有可能成为SSc特异性性功能障碍危险因素。
临床意义
临床医生需要更加关注SSc对患者性功能的影响，尤其是对有危险因素的患者。
优势与局限性
系统探讨了SSc男性和女性性功能障碍的患病率，并创新性地探索了SSc性功能障碍的危险因素。然而，纳入研究存在一些局限性，妨碍了深入探讨SSc对性功能的影响。
结论
性功能障碍可能是SSc的一个重要症状，许多危险因素可能与SSc男性和女性的性功能障碍有关。高R、卿P、孙X等。系统性硬化症患者性功能障碍的患病率及相关危险因素：一项系统综述。性医学2021；9：100392。
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