Kung I T, Hsu C, Chan S C, Leung B S, Ng D W
Department of Pathology, University of Hong Kong, Queen Mary Hospital.
Diagn Cytopathol. 1987 Dec;3(4):284-6. doi: 10.1002/dc.2840030404.
To determine the frequency of occurrence of "blue bodies" (BBs), 2,010 pulmonary cytology specimens (1,403 sputum and 607 bronchial specimens) from 1985 were reviewed. The smears were examined microscopically by transmitted and polarized light. BBs were extracellular structures, occurring most commonly in clusters but sometimes conglomerated. With Papanicolaou stain, they had a characteristic birefringent laminated brown core and a nonbirefringent blue rim. Chemical microanalysis and energy-dispersive x-ray analysis revealed that their chemical composition was calcium carbonate. A total of 233 specimens contained BBs, with a frequency of 10.5% in bronchial specimens and 12% in sputum. Only 8.6% of the BBs had co-existent pulmonary malignancy. We concluded that BBs were common structures in pulmonary cytology and were not associated with pulmonary malignancy or pulmonary fibrosis in our series. They must be distinguished from contaminants, staining artifacts, and parasitic ova.
为确定“蓝色小体”（BBs）的出现频率，我们回顾了1985年的2010份肺细胞学标本（1403份痰标本和607份支气管标本）。涂片通过透射光和偏振光进行显微镜检查。BBs是细胞外结构，最常见于聚集体中，但有时也会聚集在一起。用巴氏染色法，它们有一个特征性的双折射分层棕色核心和一个非双折射蓝色边缘。化学微量分析和能量色散X射线分析表明，它们的化学成分是碳酸钙。共有233份标本含有BBs，支气管标本中的出现频率为10.5%，痰标本中的出现频率为12%。只有8.6%的BBs与肺恶性肿瘤并存。我们得出结论，BBs是肺细胞学中的常见结构，在我们的系列研究中与肺恶性肿瘤或肺纤维化无关。它们必须与污染物、染色假象和寄生虫卵区分开来。
