隐云南酮A - H，来自于……的复杂黄烷酮

Cryptoyunnanones A-H, Complex Flavanones from .

作者信息

He Qian, Fan Yue, Liu Yu, Rao Li, You Yun-Xia, Su Yu, Zhou Zhen, Xu You-Kai, Zhang Chuan-Rui

机构信息

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, People's Republic of China.

Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Yunnan 666303, People's Republic of China.

出版信息

J Nat Prod. 2021 Aug 27;84(8):2209-2216. doi: 10.1021/acs.jnatprod.1c00287. Epub 2021 Jul 20.

DOI:10.1021/acs.jnatprod.1c00287

PMID:34282909

Abstract

Eight new complex flavanones with a novel linkage, cryptoyunnanones A-H (-), together with four known α-pyrones, were isolated from the leaves and twigs of . The structures of - including their absolute configurations were characterized by spectroscopic data analysis and single-crystal X-ray crystallography. Plausible biosynthetic pathways for the formation of compounds - were proposed. Compounds - exhibited cytotoxicity against HCT-116, MDA-MB-231, and PC-3 cancer cells with IC values from 6.4 to 9.1 μM.

摘要

从……的叶子和嫩枝中分离出了8个具有新型连接方式的新的复杂黄烷酮，即隐云南酮A - H（-），以及4个已知的α - 吡喃酮。通过光谱数据分析和单晶X射线晶体学对隐云南酮A - H的结构包括其绝对构型进行了表征。提出了化合物隐云南酮A - H形成的合理生物合成途径。化合物隐云南酮A - H对HCT - 116、MDA - MB - 231和PC - 3癌细胞表现出细胞毒性，IC值为6.4至9.1 μM。