从 中分离得到细胞毒性 α-吡喃酮衍生物。
Cytotoxic α-pyrone derivatives from .
机构信息
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, and Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University , Chongqing , P.R. China.
Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences , Menglun , P.R. China.
出版信息
Nat Prod Res. 2022 Feb;36(4):918-924. doi: 10.1080/14786419.2020.1849205. Epub 2020 Nov 19.
Five new α-pyrone derivatives, cryptoyunnanes A - E (-), together with four known analogues, were isolated from the leaves and twigs of . Their structures including absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism (ECD) analyses. Compounds and showed significant cytotoxicity against A549, HCT-116, MDA-MB-231, PC-3 and HeLa with IC values from 2.25 to 8.97 M. Compounds , and also displayed good cytotoxicity against HCT-116, MDA-MB-231 and PC-3 with IC values from 1.26 to 8.32 M. This is the first time to report the isolation and bioactivity evaluation of chemical constituents from .
从 叶片和嫩枝中共分离得到 5 个新的α-吡喃酮衍生物（cryptoyunnanes A-E），加上 4 个已知类似物。通过广泛的光谱数据和电子圆二色性（ECD）分析阐明了它们的结构包括绝对构型。化合物 和 对 A549、HCT-116、MDA-MB-231、PC-3 和 HeLa 表现出显著的细胞毒性，IC 值范围为 2.25 至 8.97 μM。化合物 、 和 对 HCT-116、MDA-MB-231 和 PC-3 也表现出良好的细胞毒性，IC 值范围为 1.26 至 8.32 μM。这是首次从 中分离得到化学成分并对其进行生物活性评价。
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