Fosså S D, Hall K S, Johannessen N B, Urnes T, Kaalhus O
Department of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo.
Eur Urol. 1987;13(6):372-7.
The cancer-related 5-year survival was 80% in 79 patients with penile cancer treated at the Norwegian Radium Hospital from 1974 to 1985 (N0 = 61, N1-2 = 12, N3 = 6). Sentinel node biopsy (SLN) of the inguinal lymph nodes medial to the saphenous vein helps to identify patients with early regional spread. The survival for these N+ patients is favourable if radical lymph node dissection is performed immediately. A tumour-negative SLN biopsy does, however, not exclude the subsequent development of inguinal lymph node metastases. These were found equally often during follow-up in patients with or without primary performance of SLN biopsy. Five of 6 patients, relapsing with groin metastases, were cured by secondary lymph node dissection. Most of the small primary tumours (T1/T2) can be treated radically by primary radiotherapy, but frequent follow-up is necessary to detect surgically curable penile recurrences (3 of 11 patients). Combination treatment of chemotherapy, radiotherapy and surgery represents a good palliation treatment in advanced cases.
1974年至1985年期间，挪威镭医院收治的79例阴茎癌患者的癌症相关5年生存率为80%（N0 = 61，N1 - 2 = 12，N3 = 6）。对隐静脉内侧腹股沟淋巴结进行前哨淋巴结活检（SLN）有助于识别早期区域扩散的患者。如果立即进行根治性淋巴结清扫术，这些N+患者的生存率良好。然而，肿瘤阴性的SLN活检并不能排除随后腹股沟淋巴结转移的发生。在有或没有先行SLN活检的患者随访期间，腹股沟淋巴结转移的发现频率相同。6例出现腹股沟转移复发的患者中有5例通过二次淋巴结清扫术治愈。大多数小的原发性肿瘤（T1/T2）可通过原发性放射治疗得到根治，但需要频繁随访以检测手术可治愈的阴茎复发（11例患者中有3例）。化疗、放疗和手术的联合治疗在晚期病例中是一种良好的姑息治疗方法。
