Fan Yonggang, Ni Shuangfei, Zhang Huafeng
Department of Orthopaedic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People's Republic of China.
Biol Trace Elem Res. 2022 May;200(5):2062-2068. doi: 10.1007/s12011-021-02845-5. Epub 2021 Jul 20.
Some studies have suggested an association between serum copper and bone density. Few studies have explored the association between copper intake and osteoporosis and bone mineral density (BMD). Our research aims to assess the associations of copper intake with the risk of osteoporosis in United States adults using the National Health and Nutritional Examination Surveys (NHANES). A total of 8224 individuals were included in our study. Osteoporosis was defined that BMD values surpass 2.5 standard deviations (SD) below the mean of the young adult reference group. Copper intake from diets and supplements was estimated by using two 24-h recall surveys. After adjustment for all the covariates of interest, the odds ratios (ORs) (95% confidence interval (CI)) between the risk of osteoporosis and total copper intake across quartiles 3 and 4 compared with quartile 1 were 0.48 (0.31-0.74) (P < 0.01) and 0.41 (0.26-0.65) (P < 0.01), respectively. The mean total femur BMD and total spine BMD of the highest dietary copper intake quartile (Cu 1.51 mg/d) was 0.03 g/cm and 0.02 g/cm greater than the lowest quartile. Our results indicate that dietary and total copper intake was positively associated with increasing BMD in US adults and negatively associated with the risk of osteoporosis in US adults.
一些研究表明血清铜与骨密度之间存在关联。很少有研究探讨铜摄入量与骨质疏松症及骨矿物质密度（BMD）之间的关联。我们的研究旨在利用美国国家健康与营养检查调查（NHANES）评估美国成年人铜摄入量与骨质疏松症风险之间的关联。我们的研究共纳入了8224名个体。骨质疏松症的定义为骨密度值低于年轻成人参考组均值2.5个标准差（SD）。通过两次24小时回顾性调查来估算饮食和补充剂中的铜摄入量。在对所有感兴趣的协变量进行调整后，与第一四分位数相比，第三和第四四分位数的总铜摄入量与骨质疏松症风险之间的比值比（ORs）（95%置信区间（CI））分别为0.48（0.31 - 0.74）（P < 0.01）和0.41（0.26 - 0.65）（P < 0.01）。膳食铜摄入量最高四分位数（铜1.51毫克/天）的总股骨骨密度和总脊柱骨密度均值分别比最低四分位数高0.03克/平方厘米和0.02克/平方厘米。我们的结果表明，美国成年人的膳食铜摄入量和总铜摄入量与骨密度增加呈正相关，与骨质疏松症风险呈负相关。
