Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, China.
Department of Medical Services Section, The Seventh Affiliated Hospital of Sun Yat-sen University, Shen'zhen, China.
PLoS One. 2024 Oct 1;19(10):e0310911. doi: 10.1371/journal.pone.0310911. eCollection 2024.
Some studies showed the possible role of copper intake on bone mineral density (BMD) in adults or the elderly, but the association remained uncertain in children and adolescents. Our research explored the association between copper intake and BMD in individuals aged 8-19 years from the National Health and Nutrition Examination Survey (NHANES) 2011-2016.
In the present study, 6,965 individuals aged 8-19 (mean age 13.18 ± 3.38 years) were enrolled from the NHANES 2011-2016. Copper intake was evaluated by averaging two 24-hour copper dietary intake recalls. Multivariate linear regression analyses were used to explore the association between copper intake and total BMD, subtotal BMD, and total spine BMD in children and adolescents. Stratified analyses and interaction tests were performed by age, gender, and race.
Participants of the higher quartile of copper intake were more likely to be older, men, Non-Hispanic White, and Other Hispanic. They have higher values of poverty income ratio (PIR), serum phosphorus, blood urea nitrogen, serum vitamin D, and BMD and lower values of body mass index (BMI), cholesterol, total protein, and serum cotinine. In the fully adjusted model, we found positive associations between copper intake and total BMD (β = 0.013, 95CI: 0.006, 0.019)), subtotal BMD (β = 0.020, 95CI: 0.015, 0.024), and total spine BMD (β = 0.014, 95CI: 0.009, 0.019). Stratified analyses showed that the association was stronger in men, individuals aged 14-19, Non-Hispanic White, and Other Hispanic.
Our study suggests that copper intake is positively associated with BMD in U.S. children and adolescents. The study emphasizes the role of copper intake on bone health in the early stages of life. However, more investigations are needed to verify our findings and their underlying mechanisms.
一些研究表明，铜的摄入量可能会影响成年人或老年人的骨密度（BMD），但在儿童和青少年中，这种关联仍不确定。我们的研究探索了 2011-2016 年国家健康和营养检查调查（NHANES）中 8-19 岁个体的铜摄入量与 BMD 之间的关系。
本研究共纳入 6965 名 8-19 岁（平均年龄 13.18±3.38 岁）的 NHANES 2011-2016 年参与者。铜摄入量通过平均两次 24 小时铜膳食摄入量回忆来评估。多元线性回归分析用于探索儿童和青少年铜摄入量与总 BMD、总骨密度和总脊柱 BMD 之间的关系。按年龄、性别和种族进行分层分析和交互检验。
铜摄入量较高四分位数的参与者更有可能年龄较大、男性、非西班牙裔白人或其他西班牙裔。他们的贫困收入比（PIR）、血清磷、血尿素氮、血清维生素 D 和 BMD 值较高，而体重指数（BMI）、胆固醇、总蛋白和血清可替宁值较低。在完全调整的模型中，我们发现铜摄入量与总 BMD（β=0.013，95%CI：0.006，0.019）、总骨密度（β=0.020，95%CI：0.015，0.024）和总脊柱 BMD（β=0.014，95%CI：0.009，0.019）之间存在正相关关系。分层分析显示，这种相关性在男性、14-19 岁的个体、非西班牙裔白人和其他西班牙裔中更强。
本研究表明，美国儿童和青少年的铜摄入量与 BMD 呈正相关。该研究强调了铜摄入量在生命早期对骨骼健康的作用。然而，还需要更多的研究来验证我们的发现及其潜在机制。
