Doctor of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bachelor of Cell Biology and Molecular-Genetics, Marand Azad University, Marand, Iran.
Inflammopharmacology. 2021 Oct;29(5):1307-1315. doi: 10.1007/s10787-021-00846-3. Epub 2021 Jul 20.
Myeloid suppressor cells (MDSCs) are an important class of immune-regulating cells that can suppress T cell function. Most of our knowledge about the function of MDSC comes from studies of cancer models. Recent studies, however, have greatly contributed to the description of MDSC involvement in autoimmune diseases. They are known as a cell population that may negatively affect immune responses by regulating the function of CD4 and CD8 cells, which makes them an attractive target for autoimmune diseases therapy. However, many questions about MDSC activation, differentiation, and inhibitory functions remain unanswered. In this study, we have summarized the role of MDSCs in various autoimmune diseases, and the potential of targeting them for therapeutic benefits has been discussed.
髓系抑制细胞（MDSCs）是一类重要的免疫调节细胞，能够抑制 T 细胞的功能。我们对 MDSC 功能的大部分了解都来自于癌症模型的研究。然而，最近的研究极大地促进了对 MDSC 参与自身免疫性疾病的描述。它们被认为是一种可能通过调节 CD4 和 CD8 细胞的功能而对免疫反应产生负面影响的细胞群体，这使得它们成为自身免疫性疾病治疗的一个有吸引力的靶点。然而，关于 MDSC 的激活、分化和抑制功能仍有许多问题尚未得到解答。在本研究中，我们总结了 MDSC 在各种自身免疫性疾病中的作用，并讨论了针对它们进行治疗的潜在益处。
