Boros Peter, Ochando Jordi, Zeher Margit
Recanati/Miller Transplant Institute, Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10129, USA.
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10129, USA.
Hum Immunol. 2016 Aug;77(8):631-636. doi: 10.1016/j.humimm.2016.05.024. Epub 2016 May 27.
Myeloid-derived suppressor cells are a heterogeneous group of immature myeloid cells with immunoregulatory function. When activated and expanded, these cells can suppress T cell functions via cell-to cell interactions as well as soluble mediators. Recent studies investigated the involvement of MDSC in autoimmune diseases. Some papers have described beneficial effect of MDSC during the course of autoimmune diseases, and suggest a potential role as a treatment option, while others failed to detect these effects. Their contributions to autoimmune diseases are not fully understood, and many questions and some controversies remain as to the expansion, activation, and inhibitory functions of MDSC. This review aims to summarize current knowledge of MDSC in autoimmune disorders.
髓源性抑制细胞是一组具有免疫调节功能的异质性未成熟髓样细胞。当被激活和扩增时，这些细胞可通过细胞间相互作用以及可溶性介质来抑制T细胞功能。最近的研究调查了髓源性抑制细胞在自身免疫性疾病中的作用。一些论文描述了髓源性抑制细胞在自身免疫性疾病过程中的有益作用，并提出了其作为一种治疗选择的潜在作用，而另一些研究则未能检测到这些作用。它们对自身免疫性疾病的贡献尚未完全了解，关于髓源性抑制细胞的扩增、激活和抑制功能仍存在许多问题和一些争议。本综述旨在总结目前关于髓源性抑制细胞在自身免疫性疾病中的知识。
