Martynov M Yu, Bogolepova A N, Yasamanova A N
Pirogov Russian National Research Medical University, Moscow, Russia.
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(6):93-99. doi: 10.17116/jnevro202112106193.
Endothelial dysfunction is an important mechanism underlying multiple organ and systems failure in COVID-19. The development of endothelial dysfunction in COVID-19 can disrupt organ perfusion and cause a procoagulant state, leading to both macro- and microvascular thrombotic events. Cognitive impairment is a common complication of COVID-19 that develop in acute and delayed periods and is not directly related to the severity of the underlying disease. Treatment of endothelial dysfunction in patients with COVID-19 should take into account the leading pathogenetic factors of its development and with the development of neurological, including cognitive, disorders should include neuroprotective drugs. One of these drugs is actovegin, which has been shown to be effective in improving endothelial function, microcirculation and cognition.
内皮功能障碍是新冠病毒感染所致多器官和系统衰竭的重要潜在机制。新冠病毒感染时内皮功能障碍的发展可破坏器官灌注并导致促凝状态，引发大、微血管血栓形成事件。认知障碍是新冠病毒感染的常见并发症，在急性期和延迟期均可发生，且与基础疾病的严重程度无直接关系。新冠病毒感染患者内皮功能障碍的治疗应考虑其发生的主要致病因素，对于出现包括认知障碍在内的神经功能障碍时，治疗应包括使用神经保护药物。其中一种药物是爱维治，已证明其在改善内皮功能、微循环和认知方面有效。
