48435Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
48435Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211042940. doi: 10.1177/10760296211042940.
The world is in a hard battle against COVID-19. Endothelial cells are among the most critical targets of SARS-CoV-2. Dysfunction of endothelium leads to vascular injury following by coagulopathies and thrombotic conditions in the vital organs increasing the risk of life-threatening events. Growing evidences revealed that endothelial dysfunction and consequent thrombotic conditions are associated with the severity of outcomes. It is not yet fully clear that these devastating sequels originate directly from the virus or a side effect of virus-induced cytokine storm. Due to endothelial dysfunction, plasma levels of some biomarkers are changed and relevant clinical manifestations appear as well. Stabilization of endothelial integrity and supporting its function are among the promising therapeutic strategies. Other than respiratory, COVID-19 could be called a systemic vascular disease and this aspect should be scrutinized in more detail in order to reduce related mortality. In the present investigation, the effects of COVID-19 on endothelial function and thrombosis formation are discussed. In this regard, critical players, laboratory findings, clinical manifestation, and suggestive therapies are presented.
全球正处于与 COVID-19 的艰难斗争中。内皮细胞是 SARS-CoV-2 的最关键靶标之一。内皮功能障碍会导致血管损伤，继而在重要器官中引发凝血异常和血栓形成，增加危及生命的事件的风险。越来越多的证据表明，内皮功能障碍和随之而来的血栓形成与疾病的严重程度有关。目前尚不完全清楚这些破坏性的后果是直接由病毒引起的，还是病毒诱导的细胞因子风暴的副作用。由于内皮功能障碍，一些生物标志物的血浆水平发生变化，同时也出现了相关的临床表现。稳定内皮完整性并支持其功能是有前途的治疗策略之一。除了呼吸系统，COVID-19 也可以被称为系统性血管疾病，应该更详细地研究这一方面，以降低相关死亡率。在本研究中，探讨了 COVID-19 对内皮功能和血栓形成的影响。在这方面，介绍了关键因素、实验室发现、临床表现和治疗建议。
