C8 补体缺陷儿童患脑膜炎奈瑟菌血清群 Z 性脑膜炎和潜在的 MenB-4C 疫苗交叉保护作用。
Neisseria meningitidis Serogroup Z Meningitis in a Child With Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine.
机构信息
From the Pediatric Infectious Diseases and Immunology, Amalia Children's Hospital, Nijmegen, the Netherlands.
Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, the Netherlands.
出版信息
Pediatr Infect Dis J. 2021 Nov 1;40(11):1019-1022. doi: 10.1097/INF.0000000000003259.
Complement deficient patients are susceptible to rare meningococcal serogroups. A 6-year-old girl presented with serogroup Z meningitis. This led to identification of a C8 deficiency. The MenB-4C vaccine induced cross-reactive antibodies to serogroup Z and increased in vitro opsonophagocytic killing and may thus protect complement deficient patients.
补体缺陷患者易感染罕见的脑膜炎奈瑟菌血清群。一名 6 岁女孩患 Z 群脑膜炎。这导致 C8 缺陷的鉴定。MenB-4C 疫苗诱导针对 Z 群的交叉反应性抗体，并增加体外调理吞噬杀伤作用，因此可能保护补体缺陷患者。
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