Sestre milosrdnice University Hospital Centre, University Hospital for Tumors, Department of Medical Oncology, Zagreb, Croatia.
Acta Clin Croat. 2020 Dec;59(4):761-764. doi: 10.20471/acc.2020.59.04.25.
Oxaliplatin is part of the standard chemotherapy regimens for treating colorectal carcinoma. Pulmonary fibrosis is a serious but rare side effect of oxaliplatin treatment, which resulted in patient death in more than half of the reported cases. The precise pathophysiological mechanism of this phenomenon has not been clarified yet. Analysis of the reported cases strongly suggests that early diagnosis and immediate corticosteroid treatment are crucial for better prognosis. Here we report a case of pulmonary fibrosis related to the FOLFOX regimen in a patient with early colorectal carcinoma.
奥沙利铂是治疗结直肠癌的标准化疗方案之一。肺纤维化是奥沙利铂治疗的一种严重但罕见的副作用，在已报道的病例中，超过一半的病例导致患者死亡。这种现象的确切病理生理机制尚未阐明。对已报道的病例进行分析表明，早期诊断和立即使用皮质类固醇治疗对于改善预后至关重要。在此，我们报告了一例早期结直肠癌患者使用 FOLFOX 方案相关的肺纤维化病例。
