Urlapu Kinnera Sahithi, Lvovsky Dmitry
Pulmonary Medicine, BronxCare Health System, Bronx, USA.
Pulmonary and Critical Care, BronxCare Health System, Bronx, USA.
Cureus. 2023 Dec 31;15(12):e51411. doi: 10.7759/cureus.51411. eCollection 2023 Dec.
Oxaliplatin is a commonly used chemotherapy drug for the treatment of gastrointestinal malignancies, but it can lead to various side effects, including interstitial lung disease (ILD), a rare but potentially fatal condition. ILD is an inflammatory and fibrotic lung disease that can cause progressive lung damage and respiratory failure. The exact mechanism by which oxaliplatin induces ILD is not known, but it is believed to be due to an immune-mediated response, or direct toxicity via oxidative stress. The symptoms of oxaliplatin-induced ILD include cough, shortness of breath, fatigue, and weight loss. Diagnosis of oxaliplatin-induced ILD requires a high index of suspicion, and imaging tests such as chest X-rays and CT scans are used to confirm the diagnosis. Treatment options for oxaliplatin-induced ILD include corticosteroids, oxygen therapy, and early cessation of oxaliplatin therapy. Early detection and prompt management are crucial to improve the prognosis of patients with oxaliplatin-induced ILD.
奥沙利铂是一种常用于治疗胃肠道恶性肿瘤的化疗药物，但它会导致各种副作用，包括间质性肺病（ILD），这是一种罕见但可能致命的病症。ILD是一种炎症性和纤维化性肺病，可导致进行性肺损伤和呼吸衰竭。奥沙利铂诱发ILD的确切机制尚不清楚，但据信是由于免疫介导的反应，或通过氧化应激产生的直接毒性。奥沙利铂诱发ILD的症状包括咳嗽、气短、疲劳和体重减轻。奥沙利铂诱发ILD的诊断需要高度怀疑，胸部X光和CT扫描等影像学检查用于确诊。奥沙利铂诱发ILD的治疗选择包括使用皮质类固醇、氧疗以及尽早停止奥沙利铂治疗。早期发现和及时处理对于改善奥沙利铂诱发ILD患者的预后至关重要。
