Zhang Yongfu, Sun Hengwen, Li Wengao, Luo Xian, Liu Ting, Fang Fan, Xiao Julan, Garg Samradhvi, Yang Yuan, Chen Yu
Department of Anesthesiology, Guangzhou Women and Children's Medical Centre, Guangzhou, Guangdong, People's Republic of China.
Department of Radiotherapy, Cancer Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, Guangdong, People's Republic of China.
Neuropsychiatr Dis Treat. 2021 Jul 12;17:2269-2280. doi: 10.2147/NDT.S321675. eCollection 2021.
Depression is a commonly seen mental health concern for mothers and fathers during their transition to parenthood. This study aims to provide new insights into the prevalence of maternal and paternal depression, its demographic and clinical correlates, and its symptom network among Chinese pregnant women and their partners.
In this multicenter, cross-sectional study, 769 pregnant women and their partners were assessed by Edinburgh Postnatal Depression Scale (EPDS) from June 15th to Sep 15th, 2020 in southern China. Convenient sampling method was used. Univariate analyses, multivariate logistic regression, and network analyses were conducted. Networks of maternal and paternal depression were compared.
In total, 60 (EPDS total score ≥13, 7.80%, 95% CI: 5.90-9.70%) women and 23 (2.99%, 95% CI: 1.78-4.20%) of these women's partners reported depression. Physical comorbidities (OR=2.664, P=0.003) was the only factor that was found to significantly correlate with maternal depression. Network analyses showed that the resulting networks were well connected and that there was significant difference of network structure between maternal and paternal depression (M=0.330, P<0.001). Centrality plot indicated that "sad or miserable" (strength=1.097) was the most central symptom in the maternal depression network, while "scared or panicky" (strength=1.091) was the most central node in the paternal network. The edge between "things have been getting on top of me" - "able to laugh and see the funny side of things" (difference: 0.153, P=0.020), and "scared or panicky" - "the thought of harming myself" (difference: 0.084, P<0.001) was significantly stronger in women's partners than that in pregnant women.
Maternal and paternal depression during pregnancy could result in significant negative consequences. Symptoms like "sad or miserable" and "scared or panicky" are critical and might be potential targets for further interventions. Evidence-based treatments, such as pharmacology, psychotherapy, community reinforcement and family training, might be beneficial for parents with depression during and after the pregnancy.
在为人父母的转变过程中,抑郁是父母常见的心理健康问题。本研究旨在深入了解中国孕妇及其伴侣中孕产妇和父源性抑郁的患病率、其人口统计学和临床相关性以及症状网络。
在这项多中心横断面研究中,2020年6月15日至9月15日期间,在中国南方采用便利抽样法,对769名孕妇及其伴侣进行了爱丁堡产后抑郁量表(EPDS)评估。进行了单因素分析、多因素逻辑回归和网络分析。比较了孕产妇和父源性抑郁的网络。
共有60名(EPDS总分≥13,7.80%,95%CI:5.90 - 9.70%)女性及其23名伴侣(2.99%,95%CI:1.78 - 4.20%)报告有抑郁。躯体合并症(OR = 2.664,P = 0.003)是唯一与孕产妇抑郁显著相关的因素。网络分析表明,所得网络连接良好,孕产妇和父源性抑郁的网络结构存在显著差异(M = 0.330,P < 0.001)。中心性图表明,“悲伤或痛苦”(强度 = 1.097)是孕产妇抑郁网络中最核心的症状,而“害怕或恐慌”(强度 = 1.091)是父源性网络中最核心的节点。“事情压得我喘不过气来” - “能笑并看到事情有趣的一面”(差异:0.153,P = 0.020)以及“害怕或恐慌” - “伤害自己的想法”(差异:0.084,P < 0.001)之间的边在女性伴侣中比在孕妇中显著更强。
孕期孕产妇和父源性抑郁可能导致严重的负面后果。“悲伤或痛苦”和“害怕或恐慌”等症状至关重要,可能是进一步干预的潜在目标。基于证据的治疗方法,如药物治疗、心理治疗、社区强化和家庭培训,可能对孕期及产后患有抑郁症的父母有益。