围绝经期巨大葡萄胎合并子痫前期和甲状腺功能亢进症：一例报告及文献复习

Wan Yan, Jiang Guoqing, Jin Ying, Hao Zengping

Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tsinghua University, Beijing 100016, China.

Open Med (Wars). 2021 Jul 10;16(1):1038-1042. doi: 10.1515/med-2021-0315. eCollection 2021.

Gestational trophoblastic disease (GTD) commonly occurs in reproductive females, but is extremely rare in perimenopausal females. In this study, we reported a case of hydatidiform mole in a 48-year-old perimenopausal female admitted due to a giant uterine mass of 28 weeks' gestational size. The serum human chorionic gonadotropin (HCG) level ranged from 944 to 1,286 mIU/mL before treatments. The signs of preeclampsia and hyperthyroidism were relatively prominent. Hysterectomy was performed and chemotherapy was scheduled when the serum HCG level remained at a plateau, about 528 mIU/mL. The symptoms of preeclampsia and hyperthyroidism were relieved after treatment. Accordingly, we concluded that GTD could occur in perimenopausal woman and hysterectomy usually is the optimal treatment.

妊娠滋养细胞疾病（GTD）常见于育龄女性，但在围绝经期女性中极为罕见。在本研究中，我们报告了一例48岁围绝经期女性葡萄胎的病例，该患者因妊娠28周大小的巨大子宫肿物入院。治疗前血清人绒毛膜促性腺激素（HCG）水平在944至1286mIU/mL之间。子痫前期和甲状腺功能亢进的体征相对突出。进行了子宫切除术，并计划在血清HCG水平维持在约528mIU/mL的平台期时进行化疗。治疗后子痫前期和甲状腺功能亢进的症状得到缓解。因此，我们得出结论，GTD可发生在围绝经期女性中，子宫切除术通常是最佳治疗方法。