Ftiha Farage, Levada Maria, Musheyev Yakubmiyer, Garrick Iana, Jiang Matthew, Ahasan Habiba
Medicine, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, USA.
Obstetrics and Gynaecology, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, USA.
Cureus. 2022 Feb 16;14(2):e22291. doi: 10.7759/cureus.22291. eCollection 2022 Feb.
Pregnancy should be suspected whenever a woman in her childbearing years misses a menstrual period. Clinical suspicion is increased if she also reports any sexual activity while not using contraception or is inconsistent in her use of contraception. Laboratory findings that aid in the diagnosis of pregnancy include the detection of human chorionic gonadotropin (hCG) in blood or urine. Hydatidiform mole (HM) is part of a group of diseases classified under gestational trophoblastic disease (GTD), which originate in the placenta and have the potential to locally invade the uterus and metastasize. Although molar pregnancies are designated as benign, they have the potential to develop into a malignancy. In this case study, we present a 48-year-old peri-menopausal female patient, with a 1+ year history of irregular menses, who presented to the clinic with signs and symptoms of pregnancy, unprotected sexual activity, and a positive at-home pregnancy test. Upon further workup of the patient, it was diagnosed that the patient had a hydatidiform molar pregnancy. It is interesting to note that benign gestational trophoblastic diseases generally occur in younger women, of "reproductive age" (generally in their twenties to early thirties), and is extremely rare in peri- and post-menopausal women.
只要处于育龄期的女性月经推迟，就应怀疑其怀孕。如果她还报告在未采取避孕措施时有过任何性活动或避孕措施使用不当，临床怀疑度就会增加。有助于诊断怀孕的实验室检查结果包括在血液或尿液中检测到人绒毛膜促性腺激素（hCG）。葡萄胎（HM）是妊娠滋养细胞疾病（GTD）分类下的一组疾病的一部分，起源于胎盘，有局部侵犯子宫和转移的可能。虽然葡萄胎妊娠被认定为良性，但它们有发展成恶性肿瘤的可能。在本病例研究中，我们介绍了一位48岁的围绝经期女性患者，有1年多月经不规律病史，因出现怀孕的体征和症状、无保护性行为及家用验孕棒呈阳性前来就诊。对该患者进一步检查后，诊断为葡萄胎妊娠。值得注意的是，良性妊娠滋养细胞疾病通常发生在“育龄期”的年轻女性（一般为二十多岁至三十出头），在围绝经期和绝经后女性中极为罕见。
