Department of Human Nutrition and Metabolomics, Pomeranian Medical University, Pomeranian Medical University, Szczecin, Poland.
Eur Rev Med Pharmacol Sci. 2021 Jul;25(13):4570-4578. doi: 10.26355/eurrev_202107_26250.
This review focuses on the role of butyrate as one of the key metabolites of gut microbiota. Butyrate along with other short-chain fatty acids, acetate and propionate, is one of the most important regulators of human metabolism. In this review, we discuss how changes in gut microbiota triggered by type 2 diabetes mellitus and its treatment (e.g., metformin) affect butyrate synthesis, how to increase butyrate production and whether there is robust evidence for the positive effects of sodium butyrate in the treatment of diabetes mellitus.
Literature review was conducted by all authors. Studies published until 27/03/2020 were included. Search words were: ("butyric acid" OR "butyrate") AND ("type 2 diabetes "OR "T2DM"). The articles selected for the study were not chosen in a systematic manner, so the evidence may not be comprehensive.
Butyrate was found to effectively reduce inflammation and plays a prominent role in the function of the intestinal barrier. To date the use of sodium butyrate in the treatment of patients with T2DM is not very popular. Meanwhile, butyric acid can beneficially modulate intestinal functions, counteracting the negative effects of the disease as well as the drugs used to treat diabetes.
T2DM is a widespread chronic disease. Understanding role of microbiota in type 2 diabetes and the mechanisms connecting T2DM and alterations in gut microbiota could be the key to improved treatment of T2DM.
本综述聚焦于丁酸作为肠道微生物群关键代谢物之一的作用。丁酸与其他短链脂肪酸（如乙酸和丙酸）一起，是调节人体代谢的最重要物质之一。在本综述中，我们讨论了 2 型糖尿病及其治疗（例如二甲双胍）引发的肠道微生物群变化如何影响丁酸的合成、如何增加丁酸的产生，以及丁酸钠在治疗糖尿病方面是否有确凿的积极作用。
所有作者均进行了文献回顾。纳入截至 2020 年 3 月 27 日发表的研究。检索词为：（“丁酸”或“丁酸盐”）和（“2 型糖尿病”或“T2DM”）。本研究中选择的文章并非系统选择，因此证据可能不全面。
丁酸可有效减轻炎症，在肠道屏障功能中发挥突出作用。迄今为止，丁酸钠在 T2DM 患者中的治疗应用并不广泛。与此同时，丁酸可以有益地调节肠道功能，抵消疾病以及用于治疗糖尿病的药物的负面影响。
2 型糖尿病是一种广泛存在的慢性疾病。了解微生物群在 2 型糖尿病中的作用以及 2 型糖尿病与肠道微生物群改变之间的联系机制，可能是改善 2 型糖尿病治疗的关键。
