[Seroprevalence of infections among patients with autoimmune diseases].

OBJECTIVE

To understand the seroprevalence of infections among patients with autoimmune diseases, so as to provide the scientific evidence for the management of toxoplasmosis in patients with autoimmune diseases.

METHODS

A total of 237 patients with definitive diagnosis of autoimmune disease were selected as the study subjects, including 79 cases with systemic lupus erythematosus, 71 cases with rheumatoid arthritis and 87 cases with inflammatory bowel disease, while 237 healthy volunteers served as controls. The serum anti- IgG antibody was detected using enzyme-linked immunosorbent assay (ELISA) in patients with autoimmune diseases and healthy controls, and the detection of serum IgG antibody against was compared between the autoimmune disease patients and healthy controls.

RESULTS

The seroprevalence of serum IgG antibody against was significantly greater in patients with autoimmune diseases than in healthy controls (29.96% vs. 4.22%; = 55.41, < 0.01), and the seroprevalence of infection was all significantly higher in patients with systemic lupus erythematosus (31.65%), rheumatoid arthritis (23.94%) and inflammatory bowel disease (33.33%) than in healthy controls ( = 45.25, 26.58 and 50.95; all values < 0.01).

CONCLUSIONS

The seroprevalence of anti- IgG antibody is significantly higher in patients with autoimmune diseases than in healthy controls, and infection may be a potential risk factor for the development of systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease.