Cao P P, Ye X F, Qian C Y
Department of Laboratory Medicine, First People's Hospital of Yuhang District, Yuhang Branch of The Second Affiliated Hospital of Zhejiang University Medical School, Hangzhou 311100, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2020 Jun 28;33(3):305-307. doi: 10.16250/j.32.1374.2020178.
To understand the seroprevalence of infections among patients with autoimmune diseases, so as to provide the scientific evidence for the management of toxoplasmosis in patients with autoimmune diseases.
A total of 237 patients with definitive diagnosis of autoimmune disease were selected as the study subjects, including 79 cases with systemic lupus erythematosus, 71 cases with rheumatoid arthritis and 87 cases with inflammatory bowel disease, while 237 healthy volunteers served as controls. The serum anti- IgG antibody was detected using enzyme-linked immunosorbent assay (ELISA) in patients with autoimmune diseases and healthy controls, and the detection of serum IgG antibody against was compared between the autoimmune disease patients and healthy controls.
The seroprevalence of serum IgG antibody against was significantly greater in patients with autoimmune diseases than in healthy controls (29.96% vs. 4.22%; = 55.41, < 0.01), and the seroprevalence of infection was all significantly higher in patients with systemic lupus erythematosus (31.65%), rheumatoid arthritis (23.94%) and inflammatory bowel disease (33.33%) than in healthy controls ( = 45.25, 26.58 and 50.95; all values < 0.01).
The seroprevalence of anti- IgG antibody is significantly higher in patients with autoimmune diseases than in healthy controls, and infection may be a potential risk factor for the development of systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease.
了解自身免疫性疾病患者中感染的血清流行率，为自身免疫性疾病患者弓形虫病的管理提供科学依据。
选取237例确诊为自身免疫性疾病的患者作为研究对象，包括79例系统性红斑狼疮患者、71例类风湿关节炎患者和87例炎症性肠病患者，同时选取237名健康志愿者作为对照。采用酶联免疫吸附试验（ELISA）检测自身免疫性疾病患者和健康对照者血清抗IgG抗体，并比较自身免疫性疾病患者与健康对照者血清抗IgG抗体的检测情况。
自身免疫性疾病患者血清抗IgG抗体的血清流行率显著高于健康对照者（29.96%对4.22%；χ² = 55.41，P < 0.01），系统性红斑狼疮患者（31.65%）、类风湿关节炎患者（23.94%）和炎症性肠病患者（33.33%）的感染血清流行率均显著高于健康对照者（χ²分别为45.25、26.58和50.95；所有P值< 0.01）。
自身免疫性疾病患者抗IgG抗体的血清流行率显著高于健康对照者，感染可能是系统性红斑狼疮、类风湿关节炎和炎症性肠病发生的潜在危险因素。
