Xiao X Z, Zhou Z M, Li Y, Xu G X, Shen G Q
Department of Laboratory Medicine, Wuxi No. 9 People's Hospital, Jiangsu Province, Wuxi 214062, China.
Wuxi Mental Health Center, Jiangsu Province, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2019 Dec 6;31(6):662-664. doi: 10.16250/j.32.1374.2019293.
To investigate the seroprevalence of infections among patients with rheumatoid arthritis, malignant tumors and schizophrenia in Wuxi City, so as to provide data support for the control of toxoplasmosis in these patients.
A total of 205 cases with definitive diagnosis of rheumatoid arthritis, 257 cases with definitive diagnosis of malignant tumors and 235 cases with definitive diagnosis of schizophrenia were recruited, while 250 healthy volunteers served as controls. The demographic features were captured from the study subjects and serum samples were collected. The serum IgG and IgM antibodies against were detected using an enzyme-linked immunosorbent assay (ELISA) in all study subjects, and the positive rates of anti-T. IgG and IgM antibodies were compared between the patients and controls.
The seroprevalence of the anti- IgG antibody was 20.98%, 24.12% and 24.68% in patients with rheumatoid arthritis, malignant tumors and schizophrenia, which were all significantly greater than in healthy controls ( = 31.54, 42.12 and 42.98, all values < 0.01), and the seroprevalence of the anti - IgM antibody was 1.46%, 2.72% and 1.70% among patients with rheumatoid arthritis, malignant tumors and schizophrenia, which were all significantly higher than in healthy controls ( = 0.06, 1.52 and 0.21, all values > 0.05).
The patients with rheumatoid arthritis, malignant tumors and schizophrenia present with higher seroprevalence of the anti-T. IgG antibody than healthy controls in Wuxi regions. Screening of infections among the patients with rheumatoid arthritis, malignant tumors and schizophrenia should be intensified to prevent the damages caused by infections.
调查无锡市类风湿关节炎、恶性肿瘤及精神分裂症患者弓形虫感染的血清流行率，为这些患者弓形虫病的防控提供数据支持。
共纳入205例确诊的类风湿关节炎患者、257例确诊的恶性肿瘤患者和235例确诊的精神分裂症患者，同时选取250名健康志愿者作为对照。收集研究对象的人口统计学特征并采集血清样本。采用酶联免疫吸附试验（ELISA）检测所有研究对象血清中抗弓形虫IgG和IgM抗体，比较患者与对照中抗弓形虫IgG和IgM抗体的阳性率。
类风湿关节炎患者、恶性肿瘤患者和精神分裂症患者中抗弓形虫IgG抗体的血清流行率分别为20.98%、24.12%和24.68%，均显著高于健康对照（χ² = 31.54、42.12和42.98，P值均<0.01）；类风湿关节炎患者、恶性肿瘤患者和精神分裂症患者中抗弓形虫IgM抗体的血清流行率分别为1.46%、2.72%和1.70%，均显著高于健康对照（χ² = 0.06、1.52和0.21，P值均>0.05）。
无锡市类风湿关节炎、恶性肿瘤及精神分裂症患者抗弓形虫IgG抗体的血清流行率高于健康对照。应加强对类风湿关节炎、恶性肿瘤及精神分裂症患者弓形虫感染的筛查，以预防弓形虫感染造成的损害。
